关键词： Caputo fractional derivatives   Karsnosels'kil's fixed point theorem   Arzela Ascoli theorem   Lyapunov function technique   trace-determinant approach   TRANSMISSION   DYNAMICS   WUHAN  

摘要： The novel coronavirus SARS-Cov-2 is a pandemic condition and poses a massive menace to health. The governments of different countries and their various prohibitory steps to restrict the virus's expanse have changed individuals' communication processes. Due to physical and financial factors, the population's density is more likely to interact and spread the virus. We establish a mathematical model to present the spread of the COVID-19 in worldwide. In this article, we propose a novel mathematical model (' $ \mathbb {S}\mathbb {L}\mathbb {I}\mathbb {I}_{q}\mathbb {I}_{h}\mathbb {R}\mathbb {P} $ SLIIqIhRP') to assess the impact of using hospitalization, quarantine measures, and pathogen quantity in controlling the COVID-19 pandemic. We analyse the boundedness of the model's solution by employing the Laplace transform approach to solve the fractional Gronwall's inequality. To ensure the uniqueness and existence of the solution, we rely on the Picard-Lindelof theorem. The model's basic reproduction number, a crucial indicator of epidemic potential, is determined based on the greatest eigenvalue of the next-generation matrix. We then employ stability theory of fractional differential equations to qualitatively examine the model. Our findings reveal that both locally and globally, the endemic equilibrium and disease-free solutions demonstrate symptomatic stability. These results shed light on the effectiveness of the proposed interventions in managing and containing the COVID-19 outbreak.

关键词： COVID-19   health care utilisation   health care seeking behaviour   Bangladesh   Cox's Bazar  

摘要： To respond to the COVID-19 pandemic, countries introduced public health and social measures that had indirect societal, economic consequences. Concerns during epidemics include continuity of routine health services. We investigate how healthcare utilisation and healthcare seeking behaviour changed during the first year of the COVID-19 pandemic among host communities in Cox's Bazar, Bangladesh. This mixed-methods study combines quantitative analyses of routine health data and population-based findings about healthcare seeking behaviours. Trends in consultations changed according to facility level (higher-level facilities included Upazila Health Complexes and District Hospitals; lower-level facilities included Community Clinics and Union Health and Family Welfare Centers). At the pandemic's beginning, drops were seen at higher-level health facilities for outpatient department (OPD) consultations, respiratory infections, and antenatal care. Minor reductions or increases were seen at lower-level facilities for the same services. Half of the subdistricts reported a cumulative increase in OPD and respiratory tract infection consultations. Most subdistricts reported a cumulative decrease in antenatal care. Child vaccinations dropped in all subdistricts, half of which did not catch-up, resulting in a cumulative decrease of delivered doses. Fear of contracting COVID-19 and financial constraints were the main reasons for decreased access. Drivers of healthcare seeking behaviours should be better understood to guide preparedness and service delivery modalities at primary and secondary levels.

关键词： COVID-19   SARS-CoV-2 variants   vaccines   health policy   Immunity   heterologous   letter   antimicrobial stewardship  

关键词： COVID-19   thromboembolism   factors associated   death   hospitalisation   VENOUS THROMBOEMBOLISM   INTERLEUKIN-6   MORTALITY   IL-6  

摘要： BackgroundThromboembolism is reported to be up to 27% in COVID-19 patients due to SARS-CoV-2 infection. Dysregulated systemic inflammation and various patient traits play a vital role in thrombosis *** assess odds and associated factors for thrombosis development among Lebanese COVID-19 *** was a case-control retrospective study conducted in January-May 2021. Patients infected with COVID-19 and developed thrombosis were classified as cases and patients who were thrombosis-free identified as control. A questionnaire assessed socio-demographics, clinical parameters, and WHO COVID-19 disease *** 267 patients, 26 (9.7%) developed thrombosis and the majority of thrombosis 34.6% was myocardial infarction, and the least (3.8%) was for catheter-related thrombosis. Results showed that the risk of thrombosis development is higher in patients with previous thromboembolic event (OR = 9.160) and previous intake of anti-hypertensive medications at home (OR = 3.116). However, females (OR = 0.330; CI: 0.118-0.925), intake of anticoagulants during hospital admission (OR = 0.126; CI: 0.053-0.300) and non-severe COVID-19 were at lower thrombosis risk (OR = 0.273). Patients who developed thromboembolic events had longer hospital stay (OR = 0.077).ConclusionPatients with COVID-19 and thromboembolism were at higher risk of mortality as compared to patients with COVID-19 but without thromboembolism. The use of anticoagulants significantly reduced the risk for thromboembolism.

关键词： Covid-19   prognosis   clinical risk prediction model   general practice   EXTERNAL VALIDATION   PROGNOSTIC MODEL   POPULATION   ALGORITHM   MORTALITY   COHORT  

摘要： Background: There is a paucity of prognostic models for COVID-19 that are usable for in-office patient assessment in general practice (GP). Objectives: To develop and validate a risk prediction model for hospital admission with readily available predictors. Methods: A retrospective cohort study linking GP records from 8 COVID-19 centres and 55 general practices in the Netherlands to hospital admission records. The development cohort spanned March to June 2020, the validation cohort March to June 2021. The primary outcome was hospital admission within 14 days. We used geographic leave-region-out cross-validation in the development cohort and temporal validation in the validation cohort. Results: In the development cohort, 4,806 adult patients with COVID-19 consulted their GP (median age 56, 56% female); in the validation cohort 830 patients did (median age 56, 52% female). In the development and validation cohort respectively, 292 (6.1%) and 126 (15.2%) were admitted to the hospital within 14 days, respectively. A logistic regression model based on sex, smoking, symptoms, vital signs and comorbidities predicted hospital admission with a c-index of 0.84 (95% CI 0.83 to 0.86) at geographic cross-validation and 0.79 (95% CI 0.74 to 0.83) at temporal validation, and was reasonably well calibrated (intercept -0.08, 95% CI -0.98 to 0.52, slope 0.89, 95% CI 0.71 to 1.07 at geographic cross-validation and intercept 0.02, 95% CI -0.21 to 0.24, slope 0.82, 95% CI 0.64 to 1.00 at temporal validation). Conclusion: We derived a risk model using readily available variables at GP assessment to predict hospital admission for COVID-19. It performed accurately across regions and waves. Further validation on cohorts with acquired immunity and newer SARS-CoV-2 variants is recommended.

关键词： covid-19   acute kidney injury   IL-8   IP-10   biomarker   HOSPITALIZED-PATIENTS   COVID-19   AKI  

摘要： Objectives: Persistent severe acute kidney injury (PS-AKI) is associated with poor clinical outcomes. Our study attempted to evaluate the diagnostic value of chemokines for early-stage PS-AKI prediction. Methods: According to the KDIGO criteria, 115 COVID-19 patients diagnosed with stage 2/3 AKI were recruited from the intensive care unit between December 2022 and February 2023. Primary clinical outcomes included detecting PS-AKI in the first week (>= KDIGO stage 2 >= 72 h). Cytometric Bead Array was used to detect patient plasma levels (interleukin-8 (IL-8), C-C chemokine ligand 5 (CCL5), chemokine (C-X-C Motif) ligand 9 (CXCL9), and interferon-inducible protein 10 (IP-10)) of chemokines within 24 h of enrollment. Results: Of the 115 COVID-19 patients with stage 2/3 AKI, 27 were diagnosed with PS-AKI. Among the four measured chemokines, only the IL-8 level was significantly elevated in the PS-AKI group than in the Non-PS-AKI group. IL-8 was more effective as a biomarker while predicting PS-AKI with an area under the curve of 0.769 (0.675-0.863). This was superior to other biomarkers related to AKI, including serum creatinine. Moreover, plasma IL-8 levels of >32.2 pg/ml on admission could predict PS-AKI risk (sensitivity = 92.6%, specificity = 51.1%). Additionally, the IL-8 level was associated with total protein and IL-6 levels. Conclusion: Plasma IL-8 is a promising marker for the early identification of PS-AKI among COVID-19 patients. These findings should be validated in further studies with a larger sample size.

关键词： Telemedicine   COVID-19   satisfaction   willingness   healthcare   UK   PATIENT SATISFACTION   CONSULTATIONS   CARE   IMPLEMENTATION   INPATIENT   FRAMEWORK   PHYSICIAN   MEDICINE   ABORTION   IMPACT  

摘要： Background: Telemedicine became a fundamental part of healthcare provision during COVID-19 pandemic. An evaluation of telemedicine-associated satisfaction helps the service develop more viable applications. This review evaluated the satisfaction of healthcare users and providers and their willingness to use this modality in ***: The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A search on empirical articles published between March 2020 and December 2022 was performed on 'PubMed' and 'Scopus' databases. Findings that reported on satisfaction of patients, families and caregivers as well as clinicians were extracted and analysed. Quality of included studies was assessed. After applying inclusion and exclusion criteria, the review included 27 eligible ***: Data was found from a variety of emergency and non-emergency departments of primary, secondary, and specialised healthcare. Almost all studies were undertaken within the NHS. There were many tools that measured satisfaction. Satisfaction was high among recipients of healthcare, scoring 9-10 on a scale of 0-10 or ranging from 73.3% to 100%. Convenience was rated high in every specialty examined. Satisfaction of clinicians was high throughout the specialities despite connection failure and concerns about confidentiality of information. Nonetheless, studies reported perception of increased barriers to accessing care and inequalities for vulnerable patients especially in older people. In general, willingness to use telemedicine in future was high in the recipients as well as the providers of ***: COVID-19 pandemic has transformed healthcare in the UK and promoted a revolution in telemedicine applications. Satisfaction was high among both recipient and provider of healthcare. Telemedicine managed to provide a continued care throughout the pandemic while maintaining social distance. The current review presented commendable e

关键词： Vascularized lymph node transfer   Lymphedema   Covid- 19   mRNA vaccination   Lymph node harvest   Donor site lymphedema   OUTCOMES  

摘要： There is evidence that COVID-19 vaccines may affect the lymphatic system. We report a case of a 40-year-old female who had undergone lymph node transfer for treating primary lymphedema of the legs. Six months later, the patient developed lymphedema of the right arm closely related to mRNA vaccination against COVID-19.

关键词： COVID-19 pandemic   financial reporting quality   audit timeliness   report delay   Ghana   Collins Ntim, University of Southampton, United Kingdom of Great Britain and Northern Ireland   G30   TIMELINESS   INSIGHTS   AUDIT  

摘要： The widespread coronavirus (COVID-19) has sparked considerable worry among businesses worldwide, including Ghana. Despite a growing body of information on market and business reactions to the COVID-19 pandemic, there are few to no studies that have empirically examined the direct impact of COVID-19 on a firm's financial reporting. The paper employed a panel regression model to examine COVID-19 impacts on a firm's financial reporting delay over 3 years for 100 firms in Ghana comprising 30 listed firms and 70 private firms. The study's empirical findings indicate COVID-19 and financial report delays have a positive and significant relationship. The study also established that the positive relationship is more pronounced for low-performing and private firms. The study recommended that a firm's operational strategies be improved and well-coordinated during pandemics to avoid reporting and subsequent operational delays.

关键词： Mental disorders   needs assessment   involuntary confinement   COVID-19   qualitative research   CARE   SERVICES   WAVE  

摘要： BackgroundThe strict isolation measures for the population imposed by the health authorities caused a prolonged disruption of informal social support networks. Both this new social situation and the decrease in accessibility to health care have generated new needs in people with severe mental illness (SMI) and their *** study provides insight into life experiences and health needs of a population with SMI during the first year of the COVID-19 pandemic in *** design using semi-structured dyadic interviews, conducted from January through December 2022. A purposive sampling of patients with SMI and their caregivers was carried out through key informants in rural and urban localities in southern Spain. Verbatims were identified and classified by triangulation after the evaluation of the interview transcripts. The codes were defined through content analysis using the NVivo ***-structured dyadic interviews (21), identifying three main categories: 1. Social isolation: increased, causing greater personal vulnerability, exacerbation of psychiatric symptoms and exhaustion in caregivers. 2. Accessibility to Health Services: decreased with fewer face-to-face consultations, with difficulty in managing urgent situations and telephone attention in decompensated and disabled patients. 3. Continuity of healthcare: decreased with distrust in health professionals due to lack of communication between primary care and the hospitalConclusionCOVID-19 confinement exacerbated loneliness and worse health self-perception in SMI people. Greater formal social support was required. GPs role is key to avoiding delays in appointments and lack of coordination between primary and specialised care.