关键词： COVID-19   Dialysis   Endothelium   Biomarkers   ICU   prognosis   ACUTE KIDNEY INJURY   MORTALITY  

摘要： Introduction: To evaluate the function of vascular biomarkers to predict need for hemodialysis in critically-ill patients with COVID-19. Methods: This is a prospective study with 58 critically-ill patients due to COVID-19 infection. Laboratory tests in general and vascular biomarkers, such as VCAM-1, Syndecan-1, Angiopoietin-1 and Angiopoeitin-2 were quantified on intensive care unit (ICU) admission. Results: There was a 40% death rate. VCAM and Ang-2/Ang-1 ratio on ICU admission were associated with need for hemodialysis. Vascular biomarkers (VCAM-1, Syndecan-1, angiopoetin-2/ anogiopoetin-1 ratio) were predictors of death and their cut-off values were useful to stratify patients with a worse prognosis. In the multivariate cox regression analysis with adjusted models, VCAM-1 [O.R. 1.13 (C.I. 95%: 1.01 - 1.27); p= 0.034] and Ang-2/Ang-1 ratio [O.R. 4.87 (C.I.95%: 1.732 - 13.719); p= 0.003] were associated with need for dialysis. Conclusion: Vascular biomarkers, mostly VCAM-1 and Ang-2/Ang-1 ratio, showed better efficiency to predict need for hemodialysis in critically-ill COVID-19 patients.

关键词： COVID-19   Fall   Hip fracture   Interrupted time series analysis   Public health restrictions  

摘要： Purpose: There is limited evidence regarding the impact of public health restrictions on hip fracture hospitalization by place of fracture occurrence. This study aimed to examine the impact of COVID-19 public health restrictions on fall-related hip fracture hospitalization rates by place of occurrence. Methods: This retrospective cohort study was conducted using hospitalization data in New South Wales, Australia, between January 2014 and June 2022. Older adults aged >= 65 years admitted to hospital following a fall-related hip fracture. An interrupted time-series analysis using autoregressive integrated moving average models evaluated the impact of public health restrictions on fall-related hip fracture hospitalization by place of fracture occurrence (home/residence, residential aged care facility (RACF), or away from usual residence). Results: The mean observed fall-related hip fracture hospitalization rate during COVID-19 public health restrictions (36.3 per 100,000 people per month) was 13.4 % lower than the forecasted rate (41.1 per 100,000 people per month). The mean observed hospitalization rates for fall-related hip fractures at home/residence, at a RACF, and away from the usual residence were 3.8 %, 18.5 %, and 40.1 % lower than the forecasted rates, respectively. Level changes in the fall-related hip fracture hospitalization rates at RACFs and away from usual residences were-0.9 per 100,000 people per month (95 % CI-1.6 to-0.2) and-1.7 per 100,000 people per month (95 % CI-2.5 to-0.9), respectively. Conclusions: There was a decline in fall-related hip fracture hospitalization rates among older adults, where the fracture occurred at RACFs and away from a person's usual residence during COVID-19 public health restrictions.

关键词： Post-COVID syndrome   Long-COVID   SARS-CoV-2   Post-viral   VALIDATION   SURVIVORS  

摘要： Background and objectives: Although many symptoms of post-COVID syndrome have been described, a comprehensive evaluation of their prevalence is lacking. We aimed to describe symptoms at 16 months from hospitalization for COVID-19. Methods: A telephone assessment was performed one year later in a cohort of COVID-19 survivors hospitalized between March and May 2020 and already evaluated four months after discharge. Patients with relevant symptoms at 16 months, patients who presented symptoms at four months, and all intensive care unit patients were invited for assessment at an outpatient facility. At telephone consultation, respiratory, cognitive, and functional symptoms were assessed. Patients underwent pulmonary function tests, lung CT scans, and psychometric and cognitive tests at the outpatient facility. Results: Among 478 patients evaluated four months after discharge, 317 (67 %) were assessed at telephone consultation and 124 at ambulatory assessment. At telephone assessment, >= 1 new symptom was reported by 216 patients (68 %), mainly fatigue (53 %), dyspnea (37 %), and memory dif ficulties (24 %). Seventy-nine patients (25 %) were asymptomatic at four months but declared >= 1 symptom one year later. In patients evaluated twice, the prevalence of cognitive impairment was 45 % at four months and 40 % at 16 months. Depression and post -traumatic symptoms prevalence remained stable, and the prevalence of anxiety signi ficantly decreased. Dysfunctional breathing was detected in 32 % of patients. At 16 months after discharge, lung CTscan exhibited abnormalities in 30/80 patients (38 %), compared to 52/85 patients (61 %) at four months. Conclusion: At 16 months after hospitalization for COVID-19, 68 % of patients declared symptoms, including patients whose symptoms appeared between 4 and 16 months. Trial registration: ***, NCT04704388 (c) 2024 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http:

关键词： SARS-COV-2 RELATED OUTCOMES   NATIONWIDE  

摘要： Objective To evaluate the influence of proton pump inhibitor (PPI) use on COVID-19 susceptibility and severity in Study design This retrospective, case-control study included all children <= 21 years undergoing COVID-19 polymerase chain reaction testing at a tertiary children's hospital between March 2020 and January 2023. The main exposure was PPI usage. The primary outcome was COVID-19 infection. The secondary outcome was COVID19 hospitalization. Log-binomial regressions were used to examine associations between PPI use and these outcomes. Results 116209 patients age 8.5 +/- 6.2 years underwent 234 867 COVID-19 tests. Current PPI use was associated with a decreased risk of COVID-19 test positivity compared with PPI nonuse [RR 0.85(95% CI 0.76, 0.94), P = .002]; however, there was a significant interaction with time of testing, and an effect of PPIs was no longer seen in the final months of the study following lessening of COVID-19 precautions [RR 1.04 (95% CI 0.0.80, 1.36), P = .77]. PPI use was not associated with risk of hospitalization in patients positive for COVID-19 after adjusting for other hospitalization risk factors [RR 0.85(95% CI 0.64, 1.13), P = .26]. Conclusions We did not find an association between PPI use and increased COVID-19 susceptibility or severity in this pediatric sample. These results provide reassuring evidence that PPIs may not worsen COVID-19 outcomes

关键词： Health registries   COVID-19   Phenotyping   OMOP   Common data model  

摘要： Objective: Norwegian health registries covering entire population are used for administration, research, and emergency preparedness. We harmonized these data onto the Observational Medical Outcomes Partnership common data model (OMOP CDM) and enrich real-world data in OMOP format with COVID-19 related data. Methods: Data from six registries (2018-2021) covering birth registrations, selected primary and secondary care events, vaccinations, and communicable disease notifications were mapped onto the OMOP CDM v5.3. An Extract-Transform-Load (ETL) pipeline was developed on simulated data using data characterization documents and scanning tools. We ran dashboard quality checks, cohort generations, investigated differences between source and mapped data, and refined the ETL accordingly. Results: We mapped 1.5 billion rows of data of 5,673,845 individuals. Among these, there were 804,277 pregnancies, 483,585 mothers together with 792,477 children, and 472,948 fathers. We identified 382,516 positive tests for COVID-19 in 380,794 patients. These figures are consistent with results from source data. In addition to 11 million source codes mapped automatically, we mapped 237 non-standard codes to standard concepts and introduced 38 custom concepts to accommodate pregnancy-related terminologies that were not supported by OMOP CDM vocabularies. A total of 3,700/3,705 (99.8%) checks passed. The 5 failed checks could be explained by the nature of the data and only represent a small number of records. Discussion and conclusion: Norwegian registry data were successfully harmonized onto OMOP CDM with high level of concordance and provides valuable source for federated COVID-19 related research. Our mapping experience is highly valuable for data partners with Nordic health registries.

关键词： Alzheimer's disease   Physical exercise   Cognitive stimulation   Telerehabilitation   OLDER-ADULTS   DEMENTIA   IMPAIRMENT   BALANCE   PEOPLE   INDIVIDUALS   STRENGTH   MOBILITY   PROGRAM   TELEREHABILITATION  

摘要： Introduction: To investigate the effect of physical exercise alone and in combination with cognitive stimulation on cognition, physical function, and quality of life in patients with Alzheimer 's Disease (PwAD). Methods: The study was a randomized controlled, single-blinded trial with pre -and post-treatment and follow-up assessments conducted at the private hospital and home environment in PwAD. Seventy-five (N = 75) participants diagnosed with AD were enrolled, but sixty (N = 60) participants (mean age 77.8 years, standard deviation (SD) 6.7) were randomized as physical exercise group (PEG) (n = 20), physical exercise and cognitive stimulation group (PE + CSG) (n = 20) and control group (CG) (n = 20). Participants in PEG and PE + CSG performed an online supervised physical exercise program (SPEP) given biweekly for 12 weeks. Additionally, the cognitive stimulation (CS) program was offered for at least three or five days for 12 weeks for PE + CSG. No treatment was given for the CG. The primary outcome measures were cognition, balance, functional mobility (FM), upper extremity muscle strength (UEMS) and lower extremity muscle strength (LEMS), and quality of life (QoL). Furthermore, depression, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were measured secondarily. Results: PE + CSG demonstrated significant improvement in cognition, balance, FM, UEMS, IADL and reduction in depression compared to the CG (p < 0.05). Besides, participants in the PE + CSG had statistically superior QoL and IADL than the PEG (p < 0.05). Conclusions: The addition of CS to the SPEP was a safe and effective method to gain statistically significant improvements in cognition, balance, FM, UEMS, IADL, and reduction in depression in PwAD.

关键词： Cryptocurrency   COVID-19 pandemic   Social isolation   Risk -taking behavior   Perceived stress   Sense of control   Neuroticism   PREDICTIVE-VALIDITY   STRESS   NEUROTICISM   INCREASES   SUPPORT   MODELS   ITEM  

摘要： This study examines the impact of social isolation on risk-taking behavior in highly uncertain environments with the potential for significant gains and losses. We uncover both direct and indirect effects of social isolation on risk-taking behavior, mediated through perceived stress, sense of control, and neuroticism. The COVID-19 pandemic provides a pertinent context to explore these dynamics, while the volatile cryptocurrency market serves as a topical context for investigation. The analysis based on covariance-based structural equation modeling (CB-SEM) of survey responses from 216 consumers reveals that social isolation significantly increases risk-taking behavior, primarily mediated by heightened perceived stress. Contrary to expectations, sense of control and neuroticism did not mediate this relationship, indicating specific pathways through which isolation affects risk decision. This finding suggests that while social isolation intensifies perceived stress, yielding riskier purchase decisions, it does not universally impact other psychological aspects like resilience (sense of control) or vulnerability (neuroticism). The observed direct (main) and indirect (mediation) effects highlight the importance of targeted interventions to address psychological well-being, particularly at times of enforced isolation. Understanding these dynamics can help advisors (e.g., financial consultants), marketers, and policymakers (e.g., government agencies/lawmakers) formulate strategies to curb excessive risk-taking among isolated individuals, particularly in high-risk financial settings.

关键词： COVID-19   Exponential random graph model   Epidemic transmission   Impact factors   Sporadic outbreaks   OMICRON VARIANT   CITIES   MODEL  

摘要： Detecting the pattern and impact factors of the persistent COVID-19 spread is essential to the national response to emerging infectious diseases in the future. Using the inter-city trajectories of the first confirmed case for each sporadic outbreak, this study constructed a city-level COVID-19 transmission network in China. The exponential random graph model (ERGM) was used to detect the COVID-19 spread pattern and examined the impact of socioeconomy, city connectivity, and their interaction on COVID-19 transmission. Results demonstrated that COVID19 transmission was strongly associated with intensive inter-city population flow, geographical proximity, and quality hospitals. During sporadic outbreaks, road or air port cities became epicentres with strong centrality. The homophily of COVID-19 transmission between natural scenery cities suggested that people wanted to travel once the restrictions were loosened but would avoid densely populated, well-developed cities. According to transmission probability estimation, well-developed cities had a higher import risk than spread risk, while border cities had a higher spread risk. Overall, the COVID-19 transmission network did not form clusters, indicating effective management of the epidemic in China during this period. This study provides valuable insights into the epidemic transmission process and proposes adaptive strategies for combating epidemics in different types of cities.

关键词： COVID-19   Employment change   Family firms   Pivoting strategy   Transparent leadership communication   AUTHENTIC LEADERSHIP   BEHAVIORAL INTEGRITY   SOCIOEMOTIONAL WEALTH   STATUS-QUO   COMMUNICATION   IMPACT   PERFORMANCE   MANAGEMENT   CAPABILITIES   INFORMATION  

摘要： The aim of this paper is to investigate the effects of different strategic behaviors adopted during COVID-19 pandemic on employment change (a percentage change in the number of employees) in both family and nonfamily firms. We use an international survey-based dataset of 2,192 family and non-family firms. We provide evidence that a pivoting strategy (transforming the business) could prevent layoffs. Finally, while transparent leadership communication positively moderates the effect of pivoting on employment change in non-family firms it shows an opposite effect in family firms.

关键词： COVID-19   Online consumption   Mobile payment   E -Commerce   Retail market   Consumer inertia   WORLD  

摘要： This study investigates the impact of the COVID-19 pandemic on the online retail market in China and explores the mechanisms underlying this relationship. By developing a theoretical model based on utility theory and consumer risk perception theory and utilizing monthly mobile payment consumption data along with the number of people diagnosed with COVID-19 at the city level in 2020, this study finds that the COVID-19 pandemic has driven an increase in the share of online consumption, thereby changing the structure of the retail market. The primary mechanism is that the pandemic boosts e-commerce activity while concurrently reducing the service quality for consumers shopping offline. Furthermore, this study confirms that online consumption has mitigated the negative impact of the pandemic on overall consumption expenditure. Heterogeneity analyses suggest that the COVID-19 pandemic has significantly increased the online share of necessity and upgraded consumption. For city heterogeneity, the effects of the pandemic on online and offline consumption structures are more pronounced in regions with larger consumption scales and lower urbanization rates. Thus, the pandemic has accelerated the development of the online retail market and strengthened consumer inertia for online channels. According to consumer inertia theory, this trend may continue even as the pandemic gradually weakens. The applicability and effectiveness of this study's conclusions and methods provide a new perspective for future research on online retail and e-commerce markets.