关键词:
Long COVID
Post-acute sequelae of SARS-CoV-2 infection
herbal medicine
fatigue
cognitive dysfunction
pilot clinical trial
AEs
Adverse events
BDI
Beck’s Depression Inventory
BIT
Bojungikgi-tang
CAM
Complementary and alternative medicine
CFQ
Cognitive Failure Questionnaire
CBD
Cheonwangbosim
ChFS
Chalder Fatigue Scale
CIS
Checklist Individual Strength
COVID
Coronavirus disease
COVID-19
coronavirus infectious disease 2019
K-BNT-15
Korean-Boston Naming Test-15
KM
Korean Medicine
MFDS
The Ministry of Food and Drug Safety
KOG
Kyungok-go
PSQI-K
the Korean version of Pittsburgh Sleep Quality Index
SARS-CoV-2
severe acute respiratory syndrome coronavirus-2
VAS
Visual Analog Scale
WAIS
Digit Span Test in Korean-Wechsler Adult Intelligence Scale
摘要:
Background Infections of Coronavirus Disease-2019 (COVID-19) can cause long-term effects known as long COVID. This pilot study aimed to evaluate the feasibility of a clinical study as well as the efficacy and safety of traditional East Asian herbal medicines in alleviating fatigue and cognitive dysfunction in patients with long COVID. Methods This prospective pilot study investigated the use of three types of herbal medicines, Bojungikgi-tang (BIT), Kyungok-go (KOG), and Cheonwangbosim-dan (CBD), for a 12-week period as potential treatments for fatigue and cognitive dysfunction in patients with long COVID. Forty-five patients with long COVID were recruited, and one of three drugs was given based on the patient’s symptoms and pattern identification. The effect of herbal medications on fatigue and cognitive function outcomes was assessed over a 36-week period, with patient adherence closely monitored. Results After 12 weeks of herbal drug administration, fatigue symptoms improved significantly across all groups, with treatment success rates of 80%, 53.33%, and 46.67% in the BIT, KOG, and CBD groups, respectively. However, cognitive dysfunction symptoms showed less improvement, with treatment success rates of 40%, 46.67%, and 13.33% in the BIT, KOG, and CBD groups, respectively. All adverse events reported were mild and unrelated to the medication. The study design was found to be feasible with high medication adherence. Conclusions This study demonstrated the feasibility of conducting a clinical trial with three herbal medicines to treat long COVID symptoms like fatigue and cognitive dysfunction