关键词： COVID-19 vaccine   adverse event following immunization   vaccine safety   alcohol swab   long-term care   older adults   CASE-DEFINITION   INJECTION SITE   GUIDELINES   COLLECTION   SYSTEM  

摘要： Despite a lack of clinical data demonstrating the effectiveness of alcohol swab cleansing prior to vaccinations as a prophylactic measure to prevent skin infections, it is recommended for vaccine administration by the Canadian Immunization Guide. The objective of this study was to evaluate the risk of adverse events after omitting alcohol skin cleansing in long-term care (LTC) residents receiving vaccinations during the COVID-19 pandemic. Two medium-sized LTC homes participated in a cohort study, whereby one LTC used alcohol swab cleansing prior to resident vaccinations and the other did not. All residents received two doses of the BNT162b2 COVID-19 vaccine separated by an average (SD) 29.3 (8.5) days. The electronic chart records of participants were reviewed by researchers blinded to group allocation to assess for the presence of adverse events following immunization (AEFI), including reactogenicity, cellulitis, abscess, or systemic reactions. Log-binomial regression was used to compute risk ratios (with 95% confidence intervals) of an AEFI according to alcohol swab status. 189 residents were included, with a total of 56 AEFI between the two doses. The risk of reactogenicity (adjusted RR 0.54, 95% CI 0.17-1.73) or systemic reactions (adjusted RR 0.75, 95% CI 0.26-2.13) did not differ for the residents that received alcohol skin antisepsis compared to those that did not. There were no cases of cellulitis or abscess. This study did not demonstrate an elevated risk of AEFI in LTC residents receiving two doses of the BNT162b2 mRNA COVID vaccine without alcohol skin antisepsis.

关键词： Covid-19   Yangtze River Delta   pm(2.5)   DNN   lockdown   SOURCE APPORTIONMENT   PARTICULATE MATTER   CHINA   POLLUTION  

摘要： The COVID-19 lockdown in early 2020 and subsequent lifting in late 2022 had a significant impact on air pollution levels in the Yangtze River Delta (YRD). Previous studies have not provided a clear understanding of the detailed spatiotemporal characteristics of PM2.5 concentrations in various functional areas of cities during different periods before and after the outbreak of the epidemic. However, by employing a deep neural network (DNN) model and integrating satellite data, meteorological reanalysis, and PM2.5 observations, established an estimation of high-resolution PM2.5 distribution during the period from 2019 to 2022. The DNN model performed well (R-2 = 0.78). During the lockdown, PM2.5 concentrations in 14 YRD cities were over 50% lower than in previous years. Interestingly, even after the lockdown was lifted, PM2.5 levels remained relatively low due to reduced human activities caused by widespread infections. Found that PM2.5 reductions varied across different intra-city functional regions during both the lockdown and lift lockdown periods. Overall, the changes in PM2.5 levels during the 2022 lift lockdown were smaller than during the 2020 lockdown. These findings emphasize the need for tailored government policies to address COVID-19's impact on air pollution, considering diverse functional areas within the region.

关键词： Covid-19   governance   lockdown   policy research   HEALTH SYSTEMS  

摘要： The COVID-19 pandemic has reflected the weaknesses in the already collapsing health systems of the countries. In India, there has been a mass exodus of migrants during the lockdown, witnessed by the world. We undertook a qualitative data analysis to examine the governance arrangements, decision-making processes and implementation of policies during the pandemic in the state of Uttar Pradesh, India. Methods We did a qualitative study using thematic analysis. The participants (n = 16) were recruited from the district(n = 4), state (n = 6) and centre (n = 6) level using purposive sampling. They participated in in-depth interviews between May 2020-July 2020 by phone/zoom. Interviews were transcribed verbatim, and data were analysed using Dedoose software. Ethical approval was obtained from the King George Medical College, Lucknow, Uttar Pradesh, vide registration ECR/262/Inst/UP/2013/RR-19 Findings We recruited participants (15 males and 1 female), and five theme categories emerged from the data analysis. These were: 1) Centralized decision-making with decentralized implementation, 2) Consultative processes for decision-making but little emphasis on consensus building, 3) Informal channels of communication and enhanced intersectoral coordination, 4) Community involvement leading to transparency, and 5) Enhanced inequities during the crisis. Results Lessons learnt from examining governance and decision-making in one state of India reveal the need for reducing inequities and attention to primary ethical considerations in times of humanitarian crisis. Going forward, we need to work towards building resilience into the health system and increasing the role of decentralized participatory decision-making and governance. The use of digital technology and social media platforms greatly facilitated the response during the pandemic and can be capitalized on more in the future as a global health policy matter.

关键词： Long COVID   machine learning   personalized medicine   predictive model for COVID-19   COVID-19 prediction   disease outcome prediction   SARS-COV-2   REGRESSION   URBAN  

摘要： SARS-CoV-2 has caused over 6.9 million deaths and continues to produce lasting health consequences. COVID-19 manifests broadly from no symptoms to death. In a retrospective cross-sectional study, we developed personalized risk assessment models that predict clinical outcomes for individuals with COVID-19 and inform targeted interventions. We sequenced viruses from SARS-CoV-2-positive nasopharyngeal swab samples between July 2020 and July 2022 from 4450 individuals in Missouri and retrieved associated disease courses, clinical history, and urban-rural classification. We integrated this data to develop machine learning-based predictive models to predict hospitalization, ICU admission, and long *** mean age was 38.3 years (standard deviation = 21.4) with 55.2% (N = 2453) females and 44.8% (N = 1994) males (not reported, N = 4). Our analyses revealed a comprehensive set of predictors for each outcome, encompassing human, environment, and virus genome-wide genetic markers. Immunosuppression, cardiovascular disease, older age, cardiac, gastrointestinal, and constitutional symptoms, rural residence, and specific amino acid substitutions were associated with hospitalization. ICU admission was associated with acute respiratory distress syndrome, ventilation, bacterial co-infection, rural residence, and non-wild type SARS-CoV-2 variants. Finally, long COVID was associated with hospital admission, ventilation, and female ***, we developed risk assessment models that offer the capability to identify patients with COVID-19 necessitating enhanced monitoring or early interventions. Of importance, we demonstrate the value of including key elements of virus, host, and environmental factors to predict patient outcomes, serving as a valuable platform in the field of personalized medicine with the potential for adaptation to other infectious diseases. Model summary and motivation. Individuals infected with SARS-CoV-2 experience a wide spectrum of clinical manifestations r

关键词： Intensive care   mechanical ventilation   post-intensive care syndrome   mental health   depression   post-traumatic stress disorder   Cuidados intensivos   ventilacion mecanica   s & iacute   ndrome post-cuidados intensivos   salud mental   depresi & oacute   n   trastorno de estr & eacute   s postraum & aacute   tico   PSYCHIATRIC-SYMPTOMS   HOSPITAL ANXIETY   SPANISH VERSION   MENTAL-HEALTH   COMORBIDITY   DISABILITY   DYSPNEA   ICU  

摘要： Background: Intensive care unit (ICU) admission and invasive mechanical ventilation (IMV) are associated with psychological distress and trauma. The COVID-19 pandemic brought with it a series of additional long-lasting stressful and traumatic experiences. However, little is known about comorbid depression and post-traumatic stress disorder (PTSD).Objective: To examine the occurrence, co-occurrence, and persistence of clinically significant symptoms of depression and PTSD, and their predictive factors, in COVID-19 critical illness ***: Single-centre prospective observational study in adult survivors of COVID-19 with >= 24 h of ICU admission. Patients were assessed one and 12 months after ICU discharge using the depression subscale of the Hospital Anxiety and Depression Scale and the Davidson Trauma Scale. Differences in isolated and comorbid symptoms of depression and PTSD between patients with and without IMV and predictors of the occurrence and persistence of symptoms of these mental disorders were ***: Eighty-nine patients (42 with IMV) completed the 1-month follow-up and 71 (34 with IMV) completed the 12-month follow-up. One month after discharge, 29.2% of patients had symptoms of depression and 36% had symptoms of PTSD; after one year, the respective figures were 32.4% and 31%. Coexistence of depressive and PTSD symptoms accounted for approximately half of all symptomatic cases. Isolated PTSD symptoms were more frequent in patients with IMV (p <=.014). The need for IMV was associated with the occurrence at one month (OR = 6.098, p = .005) and persistence at 12 months (OR = 3.271, p = .030) of symptoms of either of these two mental ***: Comorbid depressive and PTSD symptoms were highly frequent in our cohort of COVID-19 critical illness survivors. The need for IMV predicted short-term occurrence and long-term persistence of symptoms of these mental disorders, especially PTSD symptoms. The specific role of dyspnea in the

关键词： Covid   vaccine   hesitancy   minority  

关键词： COVID-19   Human resource practices   remote working   work from home   remote work effectiveness   remote work challenges   MANAGEMENT  

摘要： The COVID-19 pandemic has completely changed the landscape of organisations, which requires HR professionals to work closely with management to adapt to transformational changes. This research aims to study the impact of COVID-19 on HR practices in Singapore, focusing on remote work and communication. Realism and a deductive approach have been adopted in this Descriptive quantitative research, with the survey as the research strategy to explore remote work experiences and communications during COVID-19 in Singapore. As a cross-section study, the online questionnaire was used to collect responses from 102 employees with different backgrounds from different organisations and industries. It was found that almost half of the employees felt that the impact of COVID-19 on them was moderate, with more than 70% of employees working from home. Employees felt that government advisory was the most important information, and organisations effectively responded to COVID-19 updates. In the post-COVID-19 era, future scholars should consider what organisations and human resource departments must prepare when employees return to the office. Research contributions and implications include recommendations for remote work practices, implementation of partial remote work, good work schedule to improve efficiency and recommendations for communication practices, upgradation of IT systems and skills.

关键词： Adverse event   concept normalization   correlation analysis   COVID-19   COVID-19 vaccines   natural language processing   vaccine safety monitoring   VAERS   MEDICAL DICTIONARY   UNITED-STATES  

摘要： Introduction: The rapid development of COVID-19 vaccines has provided crucial tools for pandemic control, but the occurrence of vaccine-related adverse events (AEs) underscores the need for comprehensive ***: This study analyzed the Vaccine Adverse Event Reporting System (VAERS) data from 2020-2022 using statistical methods such as zero-truncated Poisson regression and logistic regression to assess associations with age, gender groups, and vaccine ***: Logistic regression identified 26 System Organ Classes (SOCs) significantly associated with age and gender. Females displayed especially higher odds in SOC 19 (Pregnancy, puerperium and perinatal conditions), while males had higher odds in SOC 25 (Surgical and medical procedures). Older adults (>65) were more prone to symptoms like Cardiac disorders, whereas those aged 18-65 showed susceptibility to AEs like Skin and subcutaneous tissue disorders. Moderna and Pfizer vaccines induced fewer SOC symptoms compared to Janssen and Novavax. The zero-truncated Poisson regression model estimated an average of 4.243 symptoms per ***: These findings offer vital insights into vaccine safety, guiding evidence-based vaccination strategies and monitoring programs for precise and effective outcomes.

关键词： COVID-19   diets   slum dwellers   consumers   Kenya  

摘要： The COVID-19 pandemic and associated policy responses disproportionately affected low-income households in Nairobi, Kenya. This study sought to provide empirical evidence on the responses of urban slum dwellers to the impact of COVID-19 on their diets and to determine the effectiveness of these responses. The study used four-wave balanced panel data collected during the pandemic from 437 households in Kibera and Mathare slums. To answer the research questions, the study calculated household Food Consumption Scores from the 7-day food consumption data, together with other socio-economic indicators collected in the surveys. Triangulation was also done using Key Informant Interviews with community leaders. The study employed a combination of descriptive analysis and Fixed Effects model to analyze the survey data, and content analysis for key informant data. Results show that during the COVID-19 pandemic, only 38% of slum dwellers had consistently acceptable diets, while another two-thirds (61%) of the households fluctuated between acceptable and unacceptable diets, indicating the vulnerability of urban slum dwellers' diets to food system shocks such as the COVID-19 pandemic. Household response strategies included changing consumption behavior, reorganizing household finances, reducing urban household size, prioritizing children's access to food, relying on social networks, and relying on household food production. Some coping strategies were ineffective in improving the dietary intake of urban slum dwellers. However, changing consumption behavior by eating less preferred foods was associated with improved dietary intake. Conversely, changing consumption behavior by skipping meals, eating less variety of foods, and reducing urban household size were negatively associated with improved dietary intake. The study also finds that self-employment to generate higher income played a critical role in improving the diet of slum dwellers during the COVID-19 pandemic. The findings

关键词： CEPI-CLN   standardization   immunological assays   SARS-CoV-2 pandemic   vaccine efficacy  

摘要： To date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. To convert data from each clinical assay to international standard units, the WHO international standard and the CEPI standard generated by the Medicines and Healthcare products Regulatory Agency were run in multiple facilities to determine the conversion factor for each assay. Reporting results in international units advances global understanding of SARS-CoV-2 immunity and vaccine efficacy, enhancing the quality, reliability, and utility of clinical assay data.