关键词： Vaccination   influenza   COVID-19   mRNA vaccine   seasonal vaccination   PNEUMOCOCCAL CONJUGATE VACCINE   IMMUNOGENICITY   SAFETY  

摘要： Current clinical guidelines support the concomitant administration of seasonal influenza vaccines and COVID-19 mRNA boosters vaccine. Whether dual vaccination may impact vaccine immunogenicity due to an interference between influenza or SARS-CoV-2 antigens is unknown. We aimed to understand the impact of mRNA COVID-19 vaccines administered concomitantly on the immune response to influenza vaccines. For this, 128 volunteers were vaccinated during the 22-23 influenza season. Three groups of vaccination were assembled: FLU vaccine only (46, 35%) versus volunteers that received the mRNA bivalent COVID-19 vaccines concomitantly to seasonal influenza vaccines, FluCOVID vaccine in the same arm (42, 33%) or different arm (40, 31%), respectively. Sera and whole blood were obtained the day of vaccination, +7, and +28 days after for antibody and T cells response quantification. As expected, side effects were increased in individuals who received the FluCOVID vaccine as compared to FLU vaccine only based on the known reactogenicity of mRNA vaccines. In general, antibody levels were high at 4 weeks post-vaccination and differences were found only for the H3N2 virus when administered in different arms compared to the other groups at day 28 post-vaccination. Additionally, our data showed that subjects that received the FluCOVID vaccine in different arm tended to have better antibody induction than those receiving FLU vaccines for H3N2 virus in the absence of pre-existing immunity. Furthermore, no notable differences in the influenza-specific cellular immune response were found for any of the vaccination groups. Our data supports the concomitant administration of seasonal influenza and mRNA COVID-19 vaccines.

关键词： Systematic review   meta-analysis   COVID-19 vaccine boosters   reactogenicity   adverse events   SAFETY   RISK  

摘要： IntroductionDifferent COVID-19 vaccines are being utilized as boosters. This systematic review and meta-analysis aims to evaluate the reactogenicity of COVID-19 vaccines given as booster doses, according to vaccine type, dose, timing, participant characteristics and primary immunization regimen *** databases (MEDLINE, Embase, Web of Science and CENTRAL) were searched for randomized controlled trials between 1 January 2020 and 1 January 2023 according to predetermined ***-eight studies describing 19 vaccines of four different types (viral vector, inactivated, mRNA and protein sub-unit) were identified. BNT162b2 vaccine (Pfizer-BioNTech) was selected as the control as it was most often compared with other vaccines. Fever, fatigue, headache, injection-site pain, redness, and swelling were the most frequently reported solicited events. mRNA vaccines were the most reactogenic, followed by viral vector vaccines and protein sub-unit vaccines, while inactivated vaccines were the least reactogenic. Full-dose vaccines were more reactogenic than half-dose vaccines. Heterologous BNT162b2 boosters were more reactogenic than boosters with the same vaccine used for primary ***-19 vaccine booster schedules have distinct reactogenicity profiles, dependent on dose and vaccine type, which may allow targeted recommendations and provide choice for specific populations. Greater standardization of adverse event reporting will aid future studies.

关键词： Mental health   user associations   advocacy work   peer support   digital transition   crises   COVID 19 pandemic   WELFARE-STATE   ROLES  

摘要： PurposeThis study examines how local user associations of mental health service-user organizations were affected by the pandemic, in order to provide guidance to user organizations and surrounding actors on future advancements. The pandemic is used as a case to explore organizational resilience and digitalization during *** from focus group interviews and individual interviews with representatives of ten local associations were analysed using qualitative content analysis. A theoretical framework combining governance theory and organizational theory was ***, associations swiftly restructured activities to support members to meet the urgent needs that arose, not least in relation to the digital transition. Simultaneously, face-to-face interactions was valued and some members became isolated. Public sector actors often did not prioritize collaboration, and the associations had limited agency and influence in advocacy *** organizations can play an important role in times of crisis. Surrounding social systems should provide resources to counteract resource dependencies and allow organizations to develop operating reserves. They should value collaboration and establish collaborative practices to ensure a readiness to utilize the organizations' capacities when needed. User organizations should have control over future developments, both to harness the potential of digital connectivity and to prevent a digital divide.

关键词： SARS-CoV-2   GWAS   PRS distributions   linkage disequilibrium scores   STRATIFICATION   DISPARITIES  

摘要： BackgroundGenome-wide association studies of COVID-19 severity have been carried out mostly on European or East Asian populations with small representation of other world regions. Here we explore the worldwide distribution and linkage disequilibrium (LD) patterns of genetic variants previously associated with COVID-19 *** followed up the results of a large Spanish genome-wide meta-analysis on 26 populations from the 1000 Genomes Project by calculating allele frequencies and LD scores of the nine most significant SNPs. We also used the entire set of summary statistics to compute polygenic risk scores (PRSs) and carried out comparisons at the population and continental *** observed the strongest differences among continental regions for the five top SNPs in chromosome 3. European, American, and South Asian populations showed similar LD patterns. Average PRSs in South Asian and American populations were consistently higher than those observed in Europeans. While PRS distributions were similar among South Asians, the American populations showed striking differences among *** the caveats of PRS transferability across ethnicities, our analysis showed that American populations present the highest genetic risk score, hence potentially higher propensity, for COVID-19 severity. Independent validation is warranted with additional summary statistics and phenotype data.

关键词： Post-COVID   recovery   uncertainty   higher education   illness narratives   CHILDREN   ILLNESS   HEALTH   IMPACT  

摘要： This study examines the recovery experiences of students at a university college in the Netherlands during an outbreak of COVID-19 in the spring of 2022. University policy was based on the conception of COVID-19 as short-term, with a defined recovery timeline. Despite perceptions that young people face lower risks for prolonged recovery, our study reveals a different reality. Among 36 students with COVID-19, twelve experienced symptoms for over one month. Ten semi-structured interviews revealed heterogenous recovery experiences: good, mild, moderate, and difficult. We also explored how diverse recoveries interacted with academic work. Lingering symptoms ranged from smell loss to brain fog and prolonged fatigue. The unpredictability of recovery made it difficult to attribute symptoms to COVID-19 or academic work pressure. In the context of expectations to resume academic work, some students failed to recognise their ongoing struggles. An absence of conversation regarding recovery in a demanding academic environment renders diverse recovery experiences invisible. Our findings emphasise the need for a broader conceptualisation of COVID-19 recovery amongst young people and call for further research exploring the interaction between students' illness experiences and the fast-paced academic environment.

关键词： Fear of COVID-19   urban farming motivation   resilience   life satisfaction   urban poor   Daryl O'Connor, University of Leeds, United Kingdom   Educational Psychology   Health Psychology   Education-Social Sciences   CONNOR-DAVIDSON RESILIENCE   AGRICULTURE   SCALE   FOOD  

摘要： The implementation of social restrictions during and after the COVID-19 pandemic in Malaysia significantly impacted the urban poor, exacerbated the existing challenges, and created new ones. Moreover, the psychosocial impact of these restrictions led to increased energy poverty, an adverse effect on mental health, and exacerbated the social and economic inequalities. This study identifies and analyses the influence of fear of COVID-19, resilience, urban farming motivation, and life satisfaction among the urban poor in the post-pandemic period. A total of 524 urban poor in four People's Housing Projects in Kuala Lumpur and two in the state of Pulau Pinang were invited to participate in this study. Data were collected using the Fear of COVID-19 Scale, the Connor-Davidson Resilience Scale-10, the Urban Farming Motivation Scale, and the Satisfaction with Life Scale and analysed using bivariate correlation, multiple regression analysis, and PROCESS macro. The findings indicate that there are correlations between fear of COVID-19, resilience, and life satisfaction, while urban farming motivation is directly related to resilience and life satisfaction. Therefore, policymakers are encouraged to review and redefine their urban farming programmes and policies to include fear of COVID-19, urban farming motivation, resilience, and life satisfaction when working with Malaysian urban poor communities.

关键词： Indigenous   inuit   s & aacute   mi   Arctic   COVID-19   Community-based research   collaborative approach   local knowledge   case study   pandemic   HEALTH  

摘要： The Circumpolar region, comprising the Arctic territories encircling the North Pole, is home to diverse Indigenous cultures facing unique socio-economic challenges. Indigenous communities such as the Inuit, S & aacute;mi, Athabaskan, Gwitchin, and Russian Arctic groups exhibit rich traditions and adaptive practices tied to their environments. Environmental diversity, from icy tundra to boreal forests, influences livelihoods and biodiversity, while significant socio-economic disparities persist, impacting access to healthcare, education, and economic opportunities. Against this backdrop, the global COVID-19 pandemic accentuated the intersection of environment, culture, and health in remote Arctic regions, presenting distinct challenges and opportunities. Initiated by a collaborative research project led by Fulbright Arctic Initiative Alumni, this special issue of the International Journal of Circumpolar Health explores the impacts of COVID-19 on Arctic Indigenous and rural communities. Building on previous work and recommendations, the issue features community case studies, highlighting community experiences and collaborative approaches to understand and address the pandemic's effects. The authors highlight both positive and negative societal outcomes, presenting community-driven models and evidence-based practices to inform pan-Arctic collaboration and decision-making in public health emergencies. Through sharing these insights, the special issue aims to privilege local and Indigenous knowledge systems, elevates community responses to complex and multifaceted challenges, and contributes to the evidence base on global pandemic response.

关键词： Informal trade   single mothers   socio-economic challenges   Covid 19  

摘要： This study evaluates the lived experiences of single mothers involved in informal trading in the high density suburb of Mabvuku at the height of Covid-19 induced lockdowns. Using a mixed methodology with a slant towards qualitative enquiry, the study employed focus group discussions, document analysis as well as a questionnaire. Researchers studied the environment in its natural settings and interpreted phenomena in terms of the meaning single mothers expressed in the study. An interpretive philosophy was the main anchor to the study; hence purposive sampling was used to select single mothers involved in informal trade as participants. The main objectives of the study were to determine the resilience of single mother informal traders during the Covid-19 era; analyse the socio-economic challenges faced by the single mothers in informal trade during the Covid-19 era and to explore the intervention strategies available to address challenges faced by unemployed single mothers in the Covid-19 context. Findings were analysed qualitatively through data reduction and conclusion drawing where verification of irregularities, patterns, explanations and propositions were emphasised. Quantitative aspects elicited through a questionnaire distributed to hundred single mothers were presented in tables enriched by descriptive narratives. The questionnaire profiled the demographic characteristics of respondents and type of business operated by the single mothers in the study. Overall, the study foregrounds that the introduction of lockdown restrictive measures dealt a major blow to the single mothers trading enterprises leaving most of them out of business. Whilst there were some elements of resilience and recovery, the majority of single mothers failed to cope with the strenuous environment under Covid-19.

关键词： G11   G14   I15   I18   O55   ARDL   COVID-19 pandemic   Ghana   government interventions, stock market returns   George Mudimu, Development Sciences, Marondera University of Agricultural Sciences and Technology, Marondera, Zimbabwe   Economics   Finance   Business, Management and Accounting   ECONOMIC-POLICY UNCERTAINTY   RETURNS   IMPACT  

摘要： The COVID-19 pandemic that broke out in late 2019 ushered in a rare era of global uncertainty that tested the resilience of financial and economic systems. Countries tried to implement stringent public health regulations to stop the virus's rapid spread, frequently at the expense of economic activity. We contribute to the existing body of knowledge by providing a detailed analysis of the distinct effects of government initiatives during the COVID-19 pandemic on stock market returns. We examine monthly data from February 2020 to December 2022 using the Autoregressive Distributive Lag model, focusing on both short- and long-run patterns and trends. The findings show that the COVID-19 stringency index has a short-term positive effect on stock market returns and a negative effect in the long-run. Furthermore, the findings show negative correlations between stock market returns and global economic policy uncertainty in the long run and a negative effect in the short-run. The study recommends that investors consider spreading their investments to take advantage of short-term gains during pandemic-related restrictions; listed firms should adapt their business strategies to navigate uncertainties during challenging times and finally, policymakers should enhance communication and transparency in policy decisions to build and maintain investor confidence.

关键词： COVID-19   epidemiology   grey wolf optimizer   reproductive number   92-10  

摘要： In this paper, the existing Susceptible-Infected-Recovered-Deceased (SIRD) compartmental epidemiologic process model is modified for forecasting the coronavirus effect in India. The data from India was studied for weekly fatalities, weekly infected, weekly recovered, new cases, infected and recovered individuals, Reproductive Number $ R_0 $ R0, recovery rate, death rate, and coefficient of transmission from 30 January 2020 to 31 July 2021. SARS Coronavirus 2 (SARS-CoV-2) is the Covid strain that causes Covid sickness (COVID-19), a respiratory ailment that triggered the outbreak of COVID-19 at the beginning of December 2019. We aim to provide a hybrid SIRD model for predicting the COVID-19 outbreak. In the proposed method, to improve the exploration ability of the Grey Wolf Optimizer (GWO) or to avoid stagnation in the swarm, a modified Grey Wolf Optimization Algorithm is used to optimize the initial value of Infected individuals. The modified SIRD model is further applied to get the predicted values. The data is examined on weekly basis to prevent noise. Depending on the fact, that the precise mode of transmission is highly dependent on how and when different precautions such as isolation, confinement, and other preventative measures were implemented, we put together our projections concerning satisfactory speculations based on genuine realities. The experimental results show the various trends observed in the pandemic in terms of number of peaks, increasing trend, decreasing trend, and continuous trend for infected individuals, weekly change in number of cases, weekly deaths, weekly infected, and weekly recoeverd cases of Covid-19. The proposed modified SIRD model could be a valuable tool for assessing the impact of government measures on COVID-19 outbreak.