关键词： Respiratory pathogens   coronaviruses   animal models   pathology   pathogenesis   ACUTE RESPIRATORY SYNDROME   DIPEPTIDYL PEPTIDASE 4   SARS-CORONAVIRUS   FUNCTIONAL RECEPTOR   AMINOPEPTIDASE-N   INFECTION   SARS-COV-2   MICE   PROTEIN   MERS  

摘要： Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.

关键词： Pandemic   policy   health service   evaluation   Latin America   time-series  

摘要： BackgroundThe COVID-19 pandemic prompted varied policy responses globally, with Latin America facing unique challenges. A detailed examination of these policies' impacts on health systems is crucial, particularly in Bolivia, where information about policy implementation and outcomes is *** describe the COVID-19 testing trends and evaluate the effects of quarantine measures on these trends in Cochabamba, *** COVID-19 testing data from the Cochabamba Department Health Service for the 2020-2022 period. Stratified testing rates in the health system sectors were first estimated followed by an interrupted time series analysis using a quasi-Poisson regression model for assessing the quarantine effects on the mitigation of cases during surge *** public sector reported the larger percentage of tests (65%), followed by the private sector (23%) with almost double as many tests as the public-social security sector (11%). In the time series analysis, a correlation between the implementation of quarantine policies and a decrease in the slope of positive rates of COVID-19 cases was observed compared to periods without or with reduced quarantine *** research underscores the local health system disparities and the effectiveness of stringent quarantine measures in curbing COVID-19 transmission in the Cochabamba region. The findings stress the importance of the measures' intensity and duration, providing valuable lessons for Bolivia and beyond. As the global community learns from the pandemic, these insights are critical for shaping resilient and effective health policy responses. Main findings: The findings highlight the importance of stringent quarantine measures in managing infectious disease outbreaks, offering valuable insights for policymakers worldwide in strategizing effective public health *** knowledge: By providing a detailed analysis of testing disparities and quarantine policies' effec

关键词： Butchers   covid-19   Kampala   beef   and goat's meat   Escudero-Gilete M. Luisa, Universidad de Sevilla, Spain   Agriculture   Agricultural Economics   Agriculture and Food   MEAT  

摘要： The study examined the effect of Covid-19 on butchers and their coping strategies using data collected from120 butchers in Kampala City. The results show that COVID-19 reduced volumes of meat supplied and sold, number of consumers and increased the buying and selling prices during the lockdown. After the lockdown was lifted, number of consumers, Quantity of meat supplied and sold increased but below original levels while prices continued to increase. The effects of Covid-19 were associated with butcher's experience, age, liquidity, and number of meat sources. The main coping strategies were to increase the sales price, reducing quantity bought from the source, using E-transactions and diversification to alternative economic activities mainly farming, trading and boda-boda riding. Based on results, we recommend that any support to butcher men should target youths and inexperienced butcher men to boost their liquidity and encourage them to diversify by selling different types of meat.

关键词： COVID-19 precautionary procedures   quality of services   overall Patient's satisfaction   private clinics   and Jordan   HEALTH-CARE   HOSPITALS  

摘要： The general satisfaction of patients and population about healthcare services is an indicator measurement that provides a meaningful perception of population opinion about performance of healthcare system. To study the impact of COVID-19 precautionary procedures and quality of healthcare services on patients' overall satisfaction in the Jordanian outpatient private clinics. Quantitative observational cross-sectional study was carried out targeting patients who received medical care in private clinics in Irbid/Jordan. Linear Regression was employed to perform the data analysis. A random sample of 400 respondents participated in a questionnaire. Results revealed that COVID-19 precautionary procedures and quality of healthcare services had an impact on overall patient satisfaction. The level of patient satisfaction was high across all domains examined. That means that all the producers and policies put in place during the pandemic were beneficial to patients. It is recommended that these precautions be maintained until the COVID-19 pandemic has passed. Patient satisfaction measurements give managers a more responsive system of health care delivery in response to patient wants and desires.

关键词： Work/life balance   police officers   social support   resilience   job satisfaction   PERCEIVED ORGANIZATIONAL SUPPORT   JOB-SATISFACTION   SOCIAL SUPPORT   OCCUPATIONAL STRESS   RESILIENCE SCALE   FAMILY CONFLICT   MENTAL-HEALTH   INVOLVEMENT   WORKPLACE   IMPACT  

摘要： This study has undertaken a comprehensive review of literature from 2019 to 2021, encompassing work/life balance review articles to identify the research gap in the work/life balance area. Employing the PRISMA framework for systematic literature review, the study identified prospective areas for future research on work/life balance and variables associated with work/life balance in the police sector. The articles published between 2013 and 2023 relating to the police force over the past decade were reviewed to frame a conceptual framework for the work/life balance of police officers. Further literature review attests that there is a research gap in the police sector. The primary goal is to identify the area (work/life balance in the police sector) that lacked research and establish a conceptual framework addressing the work/life balance of police officers, even in challenging situations like COVID-19. The articles related to police from 2013 to 2023 were scrutinised through the PRISMA framework to identify variables necessary for constructing the conceptual framework for police officers. This article, set in the post-COVID-19 era, delves into the factors influencing police officers' capacity to uphold a healthy work-life balance. By pinpointing those research gaps, the article proposes a conceptual framework designed to help police officers balance their professional and personal lives. Such a framework can aid organisations in formulating effective strategies for employee well-being, facilitating work-life balance even in challenging circumstances, such as those imposed by the COVID-19 pandemic.

关键词： Fourth industrial revolution   COVID-19   digital leadership   systematic review   EDUCATION  

摘要： The Fourth Industrial Revolution (4IR) has brought about significant changes in organizational leadership. However, the accelerated transformation towards digitization was not without the influence of the COVID-19 pandemic. Hence, the COVID-19 pandemic aided the digital revolution in several organizations across the globe. This paper presents global evidence from a systematic literature review on the influence of digital leadership during the COVID-19 pandemic on organizational variables such as performance, relationship, satisfaction, collaboration, expertise, effectiveness, and efficiency. A PRISMA protocol was adopted for this review, while a thorough search of the Scopus bibliographic database was used to identify 416 academic papers. Eight papers met the inclusion criteria for in-depth analysis. The findings from the selected articles showed the role that technology played in enabling leaders to navigate the complexities of this global crisis. This review revealed that digital leadership has an influence on the organizational variables considered in this study. This paper, therefore, serves as reference material in guiding administrators and school leaders in leading a new organization's digital culture. It will also aid in demonstrating digital technology-focused leadership required from school leaders.

关键词： Ai Khai   local folklore   sacred tourism   Nakhon Si Thammarat   contemporary history of southern Thai economy  

摘要： This article undertakes a critical analysis of the ascendancy of the Ai Khai (sic) cult, a religious phenomenon involving youthful spirit believed to bestow wealth and fortune, located at Wat Chedi (sic): Pagoda Temple) in modern Thai society. This spirit is deeply embedded in the religious mythologies of the Southern Thai region and have evolved into a cultural force that catalyzes economic shifts at both the local and regional levels, particularly during the economic stagnation induced by the COVID-19 pandemic. Through a nuanced examination of Ai Khai narratives set against the backdrop of the Southern Thai region's economic landscape, this study posits that the rise of the Ai Khai phenomenon is intricately linked to transformations in the capitalist economy of this geographical area. Additionally, this study explores the intertextual relationship between local folklore and canonical Buddhist narratives. By doing so, the Ai Khai narrative itself reveals a significant transformation: its evolution from a localized spectral entity to a trans-local guardian spirit. Consequently, Wat Chedi's burgeoning prosperity has emerged as an unparalleled stimulant for local economic development under Post-COVID-19 situation. The article also discusses the possible way to keep the economic growth of the area following a sustainable development goal.

关键词： A11   C12   C39   D04   D22   SMEs, top management   environmental   performance   green business, strategy   SEM   Goodness Aye, Academic Editor, University of Agriculture, Makurdi Benue State, Nigeria   Economics   finance   business, management and accounting   industry and industrial studies   accounting   business history   corporate governance   corporate social responsibility and business ethics   entrepreneurship and small business management   MANAGEMENT   ORIENTATION  

摘要： PurposeThis study aims to obtain empirical evidence on the effect of environmental analysis on environmentally friendly business strategies and performance in SMEs after the Covid-19 *** study included primary data sources such as environmental orientation, top management awareness, environmental performance, green business strategy, and SMEs performance. It involved 103 SMEs, of which 36 were in the food processing industry, 37 were in the leather processing industry, and 30 were involved in furniture *** this study, 103 SMEs were examined with a focus on performance, environmental performance, top management environmental awareness, green business strategy, and environmental orientation. These findings can support resource-based display theory and assist corporate management in making judgments regarding business plans. A positive mediation association between ecological performance and environmental orientation toward green company strategy through top management's environmental awareness was also discovered in this *** of researchA mediating relationship between environmental direction, green business strategy, and top management's ecological awareness and performance orientation is revealed, which supports managers in their ***/valueThis study focuses on green business strategies, environmental performance, environmental performance awareness, and environmental orientation to improve the operations of Indonesian SMEs and address environmental challenges. The environment is an important part and factor that must be considered in the management of business activities. The business environment influences future business development from the external and internal environment. The external environment is a factor outside the company that can influence the organizational structure, direction, internal processes and company actions in its business activities. The relationship between the e

关键词： Self-compassion   post-COVID-19 syndrome   long COVID   depression   anxiety, perceived stress   ILLNESS PERCEPTIONS   DEPRESSION   CRITICISM   VALIDITY   STRESS   HEALTH   PHQ-9   CARE  

摘要： Long COVID affects approximately 10-20% of COVID-19 patients and has a devastating impact on their quality of life and mental health. This study aimed to evaluate symptoms of psychological distress in people with long COVID and explore whether high levels of self-compassion are associated with low levels of psychological distress. An online cross-sectional survey of people with Long COVID was conducted. In total, 332 respondents participated in the survey. All dimensions of self-compassion were found to be significantly associated with depression, anxiety, and perceived stress, independent of symptom severity. Specifically, self-kindness, common humanity, and mindfulness were strongly negatively associated with distress, whereas self-judgment, isolation, and over-identification were strongly and positively associated with distress. Self-compassion seems to play a role in explaining levels of psychological distress in people with long COVID symptoms. The centrality of self-compassion may lead to the development of effective interventions to help patients with long COVID reduce self-judgmental and self-critical tendencies and improve their psychological well-being.

关键词： Phenytoin derivative   COVID-19   Green biological study   Molecular docking   Crystal structure   Hirshfeld surface analysis (HSA)   MOLECULAR-STRUCTURE   COMPLEXES   CONFORMATION   STABILITY   EPILEPSY  

摘要： That's an interesting point! Phenytoin's potential in reducing cognitive deficits during COVID-19 is indeed intriguing. Its established status as an approved antiepileptic medication could lend credibility to exploring its effects on cognitive function in COVID-19 patients. This dual functionality could provide a unique angle for research and potential therapeutic interventions. This study reports the synthesis, characterization and importance of a new phenytoin derivative PD, C23H24N4O5. A biological molecular modelling study using a computeraided tool, which is a clean technique of PD compared to the approved Phenytoin anti-COVID-19 drugs, was achieved. Docking the three compounds into 7JQ0 of COVID-19 Mpro showed the potential capability of PD compared to Phenytoin and the inhibitor. Binding affinity, for example, was -7.3, -6.9 and -6.6 kcal/mol, respectively. Noticeably, PD interacted with 75 % of the essential functional Mpro amino acids, such as G143 and H164, M49, C145, M165 and E166, comparable to the standards used. Further interesting findings that predicted compound toxicity and drug-likeness also found that PD was less toxic and bio-available as a drug than Phenytoin and the inhibitor. Superposition of our ligand PD against Phenytoin and the Inhibitor docked into7JQ0 using the same parameters showed similar interactions in the amino acid cavity, enhancing the possibility of PD being an anti-COVID-19 drug. The free computer-aided methods were used to significantly speed up the initial stages of drug discovery by narrowing down potential candidates for further laboratory testing. This compound adopts an L-shaped conformation. The lone pairs on the ring nitrogen atoms participate in pi bonding in the ring. In the crystal, a layer structure was generated by N-H & sdot;& sdot;& sdot;N, N-H & sdot;& sdot;& sdot;O and C-H & sdot;& sdot;& sdot;O hydrogen bonds plus C-H & sdot;& sdot;& sdot;pi(ring) interactions. Theoretical studies of the compound were calculat