关键词： Remote training   Professional development   Math coaching   Early numeracy   MATHEMATICS   ACHIEVEMENT   REPLICATION   INSTRUCTION   EDUCATION   SCIENCE  

摘要： Early numeracy skills are vital for kindergarten students because they provide the foundation for acquiring mathematics skills in both kindergarten and subsequent years. Teacher support to intervene with kindergarteners at risk for poor mathematics learning outcomes is a promising approach to addressing this achievement gap. The current study replicates previous work on an established early numeracy intervention, ROOTS. In this instance, ROOTS uses remote professional development as a novel format for interventionist training support during the COVID-19 pandemic. Findings indicate that interventionists receiving remote support for implementing ROOTS found training and coaching acceptable and feasible. Remote training and coaching supported strong levels of implementation fidelity. Furthermore, children who received the ROOTS intervention outperformed their control group peers on post-test measures of mathematics achievement within a randomized controlled trial research design. Outcomes and implications for using remote professional development as a format for supporting educators in their use of early numeracy intervention programs are discussed within a pandemic-response context.

关键词： cognitive-behavioral therapy   adolescents   anxiety   depression   family conflict   DYSTHYMIC DISORDER   EMOTIONAL DISORDERS   COMORBID ANXIETY   CHILDREN   SYMPTOMS   BEHAVIOR   THERAPY   CBT  

摘要： Anxiety and depression are two of the most common mental health disorders diagnosed in adolescents. While either disorder individually creates impairments in psychological, emotional, and social functioning, these disorders often co-occur and reciprocally influence one another which can lead to continual worsening in functioning over time. Specifically with adolescents, anxiety and depression are associated with interpersonal conflicts with family and friends, which can further contribute to disruptions in functioning. This case study explores the effectiveness of using cognitive behavioral therapy (CBT) with a 14-year-old white male with generalized anxiety disorder (GAD) and persistent depressive disorder (PDD) via telehealth during the COVID-19 pandemic. Treatment was divided into two phases, with the first phase occurring over 20 sessions and the second phase occurring over nine sessions for a total of 29 sessions. In the first phase, the Unified Protocol for Adolescents (UP-A) was flexibly implemented to target emotion regulation, behavioral skills, and cognitive restructuring. The second phase focused on family dynamics and targeted effective communication and collaborative problem-solving. Outcome data showed significant reductions in anxiety symptoms and slight reductions in depressive symptoms as well moderate improvements in peer relationships. These results provide support for using the UP-A to target internalizing symptoms in adolescents but also highlight the importance of addressing the family system in treatments. Treatment implications and recommendations for clinicians are discussed.

关键词： Indian Women Entrepreneurs   Resilience   Crisis   Positive   Networking   Support   FIT INDEXES   PERSPECTIVE   BUSINESS   VALIDITY   SUCCESS   GROWTH  

摘要： Although enough research has been carried out on factors inspiring women to start and operate business, there is a need to assess the role of various factors impacting resilience of Indian women entrepreneurs. Women entrepreneurs all over the world are struggling, adapting diverse strategies and innovating in the face of COVID-19, to fight against the crisis and bouncing back to their normal stage. The present study aims at identifying the direct relationships among selected factors in influencing the resilience of women entrepreneurs. The sample for the study comprised 396 women entrepreneurs from different regions of India. This is a survey-based study; a self-administered questionnaire was used for the collection of data. Analysis of the data collected was done using analysis of moment structures based structural equation modelling. Findings of the analysis state a significant and positive influence of entrepreneurial characteristics, resourcefulness, networking, adaptability and continuity in forming the resilient attitude of women entrepreneurs when faced with a crisis situation. The study can be useful to women entrepreneurs, organizations, government and other institutions extending support to entrepreneurs.

关键词： brain abscess   complicated bacterial infection   empyema   mastoiditis   retropharyngeal abscess   CHILDREN   IMPACT  

摘要： Aim: After the relaxation of COVID-19 mitigation measures, we observed a dramatic increase in pyogenic infections. Based on this observation, we retrospectively analysed all cases of invasive bacterial infections of brain, lung and complicated ear-nose-throat (ENT) infections, in the period from 1 August to 31 March from the years 2018-2019 to 2022-2023. Methods: The study was conducted in two Paediatric Emergency Departments, at IRCCS 'Burlo Garofolo' of Trieste and at Treviso Hospital. Electronic medical records were searched for all cases with a definitive diagnosis at discharge of mastoiditis, suppurative cervical lymphadenitis, retropharyngeal, parapharyngeal and peritonsillar abscess (ENT group), bacterial brain abscesses, epidural empyema, subdural empyema (central nervous system group), thoracic empyema and necrotising pneumonia (lung group). Results: In 2022-2023, we observed an increase in infections compared to the previous years. Total number of cases were 22, 29, 8, 27 and 63 in 2018-2019, 2019-2020, 2020-2021, 2021-2022 and 2022-2023, respectively. The greater increase occurred in thoracic empyema, with a peak incidence of +120% in 2022-2023 in respect of 2021-2022. Conclusion: We reported an important increase in paediatric bacterial complicated infections in two North East Italian regions, possibly correlated with the relaxation of COVID-19 social distancing measures.

关键词： agricultural commodity   COVID-19   Long Short-Term Memory   machine learning   recession   United States   GARCH MODELS   OIL PRICE   VOLATILITY   FUTURES   MARKETS   PREDICTION   DOLLAR   IMPACT   TESTS   US  

摘要： We employ a neural network (NN) approach-Long Short-Term Memory (LSTM)-to study agricultural commodity prices during the 2008 Great Recession and the COVID-19 recession. Our analysis reveals more structural breaks and higher volatility in plant-based commodities like corn and soybeans during recessions compared with animal-based commodities. The price reactions varied among commodities, with corn responding first to both recessions, while milk price, which was found independent of other prices, recovered last from the financial recession and first from the disease-induced recession. This insight into commodity behavior during recessions can aid in trend prediction and recession preparation for investors and researchers.

关键词： plasma proteomics   fractionation   data-independentacquisition   COVID-19   DIA-NN   biomarkers   deep proteome analysis   clinical proteomics   BIOMARKER DISCOVERY  

摘要： Plasma proteomics is a precious tool in human disease research but requires extensive sample preparation in order to perform in-depth analysis and biomarker discovery using traditional data-dependent acquisition (DDA). Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly improve proteome coverage and depth while remaining cost-efficient. Using human plasma collected from a 20-patient COVID-19 cohort, our method utilizes commonly available solutions for depletion, sample preparation, and fractionation, followed by 3 liquid chromatography-mass spectrometry/MS (LC-MS/MS) injections for a 360 min total DIA run time. We detect 1321 proteins on average per patient and 2031 unique proteins across the cohort. Differential analysis further demonstrates the applicability of this method for plasma proteomic research and clinical biomarker identification, identifying hundreds of differentially abundant proteins at biological concentrations as low as 47 ng/L in human plasma. Data are available via ProteomeXchange with the identifier PXD047901. In summary, this study introduces a streamlined, cost-effective approach to deep plasma proteome analysis, expanding its utility beyond classical research environments and enabling larger-scale multiomics investigations in clinical settings. Our comparative analysis revealed that fractionation, whether the samples were pooled or separate postfractionation, significantly improved the number of proteins quantified. This underscores the value of fractionation in enhancing the depth of plasma proteome analysis, thereby offering a more comprehensive landscape for biomarker discovery in diseases such as COVID-19.

关键词： SARS-CoV-2   COVID-19   Vaccine   Booster   mRNA   Socio-economic status   OMICRON   SYSTEM   LINE  

摘要： Objectives: Socio-economic status (SES) disparities exist in the uptake of COVID-19 vaccination; however, most studies were conducted during the initial pandemic wave when vaccination was less discretionary, limiting generalizability. We aimed to determine whether differences in vaccination uptake across SES strata widened after the removal of vaccination -differentiated measures prior to the rollout of the second boosters, in a nationwide cohort of older Singaporeans at higher risk of severe-COVID-19. Study design: Retrospective population -based cohort study. Methods: Retrospective population -based cohort study of all Singaporeans aged >= 60 years from 22nd February 2021 -14th February 2023. Cox regression models controlling for demographics and comorbidities were used to estimate hazard -ratios (HRs) for the uptake of primary vaccination as well as first/ second boosters, as recorded in the national vaccination registry, according to SES (housing type). Results: 836,170 individuals were included for completion of a primary vaccine series; 784,938 individuals for completion of the first booster and 734,206 individuals for the completion of the second booster. Differences in vaccination uptake by SES strata were observed (e.g. vaccination uptake in lowestSES [1-2 room public -housing] versus highest-SES [private housing]: second booster, 47.6% vs. 58.1%; first booster, 93.9% vs. 98.0%). However, relative differences did not markedly widen during second booster rollout when vaccination was more discretionary (e.g. amongst those aged 60-69 years: 0.75 [95% CI = 0.73-0.76] for the first booster; 0.81 [95% CI = 0.79-0.84] for the second booster). Conclusion: While differences in vaccination uptake across SES strata by housing type persisted during the rollout of primary vaccination and subsequent boosters in a nationwide cohort of older Singaporeans, differences did not widen substantially when vaccination was made more discretionary. (c) 2024 The Royal Society for Pu

关键词： NORMATIVE DATA  

摘要： Objective: Persisting neurological symptoms after COVID-19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post-COVID syndrome (PCS). Methods: Using resting-state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.4 +/- 11.6 years; F:M = 38:9) and 47 individually matched healthy control participants. Group differences were calculated using two-sample t-tests. Multivariable linear regression was used for associations of each regional perfusion and oxygen level measure with cognition and sleepiness measures. Exploratory hazard ratios were calculated for each brain metric with clinical measures.
Results: Patients presented with high levels of fatigue (79%) and daytime sleepiness (45%). We found widespread decreased brain oxygen levels, most evident in the white matter (false discovery rate adjusted-p-value (p-(FDR)) = 0.038) and cortical grey matter (p-(FDR) = 0.015). Brain perfusion did not differ between patients and healthy participants. However, delayed patient caudate nucleus perfusion was associated with better executive function (p-(FDR) = 0.008). Delayed perfusion in the cortical grey matter and hippocampus were associated with a reduced risk of daytime sleepiness (hazard ratio (HR) = 0.07, p = 0.037 and HR = 0.06, p = 0.034). Decreased putamen oxygen levels were associated with a reduced risk of poor cognitive outcome (HR = 0.22, p = 0.019). Meanwhile, lower thalamic oxygen levels were associated with a higher risk of cognitive fatigue (HR = 6.29, p = 0.017). Interpretation: Our findings of lower regional brain blood oxygen levels suggest increased cerebral metabolism in PCS, which potentially holds a compensatory function. These hemodynamic changes were related to symptom severity, possibly representing metabolic adaptations.