关键词： Last mile delivery   self-collection   integrated choice and latent variable model   stated choice experiment  

摘要： The economic and environmental challenges associated with Last Mile Delivery (LMD) give rise to the self-collection concept, yet the practical adoption is often below expectations. In this consumer-centric segment, adequate understandings of consumers are vital but are often lacking. To address this gap, this study examines consumers' LMD preference with the Integrated Choice and Latent Variable framework. A stated choice experiment was commissioned in Singapore during the transition of COVID pandemic toward endemic. Our results showed that consumers accept unattended delivery methods and are no longer concerned with the delivery time window, a traditionally critical delivery attribute. Regarding latent perceptions, this study confirmed the significant effects of value perception on self-collection preferences. Nonetheless, individuals' environmental consciousness was found to be insignificant. The relative effects of specific value statements were quantified using the marginal rate of substitution and the mediation roles of value perception on the sociodemographic-preferences relationships were validated.

关键词： COVID-19   Silica nanocomposites   Druglikeness   FMOs   Ligand-protein interactions   ELECTRON LOCALIZATION FUNCTION   DRUG  

摘要： Favipiravir (FAV) a promising therapeutic candidate for addressing COVID-19, has attracted significant attention in recent times. In an attempt to optimize its delivery and minimize its toxicity, this investigation delves into the utilization of gold, silver, and platinum loaded silica nano composites as dopants with FAV molecule, which serves as nano structured materials. The main goal of this research is to augment the efficiency of drug delivery and concurrently diminish the harmful effects associated with FAV administration. To achieve this, the structural and physicochemical characteristics of the nano composites are meticulously evaluated with quantum chemical calculations. A theoretical prediction of the interaction dynamics between FAV and the nanocomposites is conducted. The adsorption energies computed in this investigation indicate that FAV exhibits a greater attraction towards the Au, Ag, and Pt loaded silica nano composites. By the utilization of Surface Enhanced Raman Spectroscopy (SERS), the adsorption behavior of FAV and its interaction with the nano composites were examined. The addition of nano composites onto the surface of FAV led to notable alterations in the energy level of the frontier molecular orbitals, thereby leading to a reduction in the energy gaps. The examination of druglikeness makes a valuable contribution to the advancement of medication protocols related to FAV and offer valuable understanding into the bioactivity. Molecular docking was conducted on both the molecule (FAV) and its derivatives doped with silica nano composites, and the results explored the manner in which FAV and its derivatives interacted with the designated proteins. Overall, these findings proposed that the Au, Ag, and Pt loaded silica nano composites are efficient aspirants for the development of the FAV anti-COVID-19 drug delivery process.

关键词： coronary artery disease   COVID-19   optical coherence tomography   PLAQUE EROSION  

摘要： COVID-19 may predispose patients to cardiac injuries but whether COVID-19 infection affects the morphological features of coronary plaques to potentially influence the outcome of patients with coronary artery disease (CAD) remains unknown. By using optical coherence tomography (OCT), this study compared the characteristics of coronary plaque in patients with CAD with/without COVID-19 infection. The 206 patients were divided into 2 groups. The COVID-19 group had 113 patients between December 7, 2022, and March 31, 2023, who received OCT assessment after China decided to lift the restriction on COVID19 and had a history of COVID-19 infection. The non-COVID-19 group had 93 patients without COVID-19 infection who underwent OCT before December 7, 2022. The COVID19 group demonstrated a higher incidence of plaque ruptures (53.1% vs 38.7%, p = 0.039), erosions (28.3% vs 11.8%, p = 0.004), fibrous (96.5% vs 89.2%, p = 0.041) and diffuse lesions (73.5% vs 50.5%, p <0.001) compared with the non-COVID-19 group, whereas non-COVID-19 group exhibited a higher frequency of cholesterol crystals (83.9% vs 70.8%, p = 0.027), deep calcifications (65.6% vs 51.3%, p = 0.039) and solitary lesions (57.0% vs 34.5%, p = 0.001). Kaplan-Meier survival analysis revealed a significantly lower major adverse cardiac events-free probability in the COVID-19 group (91.6% vs 95.5%, p = 0.006) than in the non-COVID-19 group. In conclusion, OCT demonstrated that COVID-19 infection is associated with coronary pathological changes such as more plaque ruptures, erosions, fibrosis, and diffuse lesions. Further, COVID-19 infection is associated with a higher propensity for acute coronary events and a higher risk of major adverse cardiac events in patients with CAD. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Mindfulness   Neuroscience   COVID-19   wellness   contemporary art   SINGLE-SESSION MEDITATION   FOCUSED-ATTENTION   TOP-DOWN   HEALTH   MINDFULNESS   STATES  

摘要： In 2020, the COVID-19 pandemic caused mandatory lockdowns worldwide, exacerbating mental health issues created by social isolation. Aimed to improve mental health and maintain engagement, the Singapore Art Museum (SAM) rapidly deployed an online programme called Unwind with SAM to engage the public with the museum's contemporary art collection coupled with meditation. The programme focused on the positive effect of arts on mental health, combined with the cognitive benefits of meditation by 'slow-looking' at artworks. This practice-based report reflects on the processes and explores the potential between art, contemplation and cognitive sciences. The first section outlines the current landscape of art and wellness approaches in museums. The second section explains the philosophical framework that guides the programme, alongside a breakdown of components and design rationale. The final part provides a critical reflection and concludes with recommendations for practitioners, managers and scientists to utilise the framework for designing future programmes.

关键词： COVID-19   high altitude   prevalence   SARS-CoV-2  

摘要： Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stephane Doutreleau, Emeric Stauffer, Aurelien Pichon, Julien V. Brugniaux, Helene Pere, Pierre Bouzat, David Veyer, and Samuel Verges. High-altitude environment and COVID-19: SARS-CoV-2 seropositivity in the highest city in the world. High Alt Med Biol. 22: 000-000, 2021. Background: A reduced coronavirus disease 2019 (COVID-19) diffusion has been suggested in high-altitude areas but remained questionable. Aims of this study were to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity as well as the risk factors associated in La Rinconada, the highest city in the world (5,100-5,300 m), a gold-mining town located in southeastern Peru where >50,000 dwellers live in precarious sanitary conditions. Materials and Methods: We performed a cross-sectional study during a 1-week period in October 2020, using point-of-care lateral flow serological assays allowing detection of antibodies directed against SARS-CoV-2 among voluntary dwellers in La Rinconada. Participants were also questioned about potential occupational and environmental risk factors of COVID-19 occurrence. Results: In a sample of 159 dwellers tested in La Rinconada, 48.4% [95% confidence interval, CI: 40.5-56.4] were seropositive for the SARS-CoV-2. Occurrence of at least one symptom compatible with the COVID-19 over the past 6 months remained the only significant factor associated with SARS-CoV-2 seropositivity (adjusted odds ratio: 3.27; [95% CI: 1.70-6.44]; p < 0.001). Conclusions: The high rate of SARS-CoV-2 seropositivity observed in this small sample of highlanders does not support a protective effect of high-altitude against the COVID-19 spread and demonstrates its large dissemination in vulnerable populations. Clinical Trial Registration number: NCT04604249.

关键词： Covid-19   alcohol consumption   health communication   CMO low-risk drinking guidelines   message tailoring   HEALTH RESPONSIBILITY DEAL   WARNING LABELS   PUBLIC-HEALTH   DRINKING   KNOWLEDGE   DRINKERS   IMPACT  

摘要： Objective: Research shows that personal relevance may affect the impact of alcohol-related health information. This study explored alcohol consumption during the UK Covid-19 lockdown, and whether a message emphasising the effect of alcohol on the immune system was more effective in altering intentions to follow low-risk drinking guidelines than other messages about the effects of alcohol on *** & Measures: From April to June 2020, 953 drinkers completed an online questionnaire, and were randomly allocated to exposure to a control condition or one of three messages emphasising the impact of alcohol on: the immune system; mental health; or physical health. Outcome variables were: concern about alcohol intake, and intention to adhere to low-risk drinking ***: Pre-post ANCOVAs revealed that participants in the immunity message group had significantly stronger intention to adhere to low-risk guidelines than the control group (after controlling for initial intention). Concern for the effect of alcohol on health was not significantly ***: During Covid-19 lockdown, a message emphasising the impact of alcohol on the immune-system had a greater effect on intention to observe low-risk drinking guidelines than other messages. Contextually relevant messages could be used for alcohol health campaigns and for improving alcohol labelling.

关键词： 阿兹夫定   新型冠状病毒感染   危险因素   用药安全性  

摘要： 目的分析阿兹夫定对新型冠状病毒感染(COVID-19)>60岁老年住院患者中的有效性、安全性以及影响临床结局的危险因素,为临床用药提供参考。方法采用回顾性研究方法,选取因COVID-19住院且使用阿兹夫定片的108例患者为研究对象,根据患者临床结局分为有效组和生存组;根据患者有无使用中药饮片分为无中药饮片组和中药饮片组。连续变量采用Pearson相关性分析,分类变量采用Spearman相关性分析。结果2组患者年龄、性别、体质量指数、吸烟史、基础病等差异无统计学意义(P>0.05)。2组诊断分型、合并症、用药前病程、是否联用中药饮片差异具有统计学意义(P<0.05)。缺血性脑血管病、贫血、低钠血症、低蛋白血症是影响COVID-19临床结局的危险因素。结论阿兹夫定对于COVID-19轻、中型效果较好。联合使用中药饮片、早期用药对于患者病情改善具有显著作用,合并症影响治疗结局。