关键词： recovered COVID-19   long COVID   MRI   circulating biomarkers   functional assessment   SKELETAL-MUSCLE   IMAGES   MOLLI  

摘要： Introduction: Short-term clinical outcomes from SARS-CoV-2 infection are generally favorable. However, 15-20% of patients report persistent symptoms of at least 12 weeks duration, often referred to as long COVID. Population studies have also demonstrated an increased risk of incident diabetes and cardiovascular disease at 12 months following infection. While imaging studies have identified multi-organ injury patterns in patients with recovered COVID-19, their respective contributions to the disability and morbidity of long COVID is unclear. Methods: A multicenter, observational study of 215 vaccine-na & iuml;ve patients with clinically recovered COVID-19, studied at 3-6 months following infection, and 133 healthy volunteers without prior SARS-CoV-2 infection. Patients with recovered COVID-19 were screened for long COVID related symptoms and their impact on daily living. Multi-organ, multi-parametric magnetic resonance imaging (MRI) and circulating biomarkers were acquired to document sub-clinical organ pathology. All participants underwent pulmonary function, aerobic endurance (6 min walk test), cognition testing and olfaction assessment. Clinical outcomes were collected up to 1 year from infection. The primary objective of this study is to identify associations between organ injury and disability in patients with long-COVID symptoms in comparison to controls. As a secondary objective, imaging and circulating biomarkers with the potential to exacerbate cardiovascular health were characterized. Discussion: Long-term sequelae of COVID-19 are common and can result in significant disability and cardiometabolic disease. The overall goal of this project is to identify novel targets for the treatment of long COVID including mitigating the risk of incident cardiovascular disease.

关键词： Coronavirus  

摘要： When it came to Covid-19, timing was everything. This paper considers the spatiotemporal dynamics of the Covid-19 pandemic via a developed methodology of non-Euclidean spatially aware functional registration. In particular, the daily SARS-CoV-2 incidence in each of 380 local authorities in the UK from March to June 2020 is analysed to understand the phase variation of the waves when considered as curves. This is achieved by adapting a traditional registration method (that of local variation analysis) to account for the clear spatial dependencies in the data. This adapted methodology is shown via simulation studies to perform substantially better for the estimation of the registration functions than the non-spatial alternative. Moreover, it is found that the driving time between locations represents the spatial dependency in the Covid-19 data better than geographical distance. However, since driving time is non-Euclidean, the traditional spatial frameworks break down; to solve this, a methodology inspired by multidimensional scaling is developed to approximate the driving times by a Euclidean distance which enables the established theory to be applied. Finally, the resulting estimates of the registration/warping processes are analysed by taking functionals to understand the qualitatively observable earliness/lateness and sharpness/flatness of the Covid-19 waves quantitatively. © 2024, CC BY.

关键词： human milk banking   emergency   COVID-19 pandemic   war in Ukraine   infant feeding   INFANT  

摘要： Introduction In recent years, Poland has faced two major emergencies: the COVID-19 pandemic, a global-scale public health emergency in 2020, and the outbreak of a full-scale war in Ukraine, which forced over 9 million Ukrainians-mostly women and children-to flee from their country through the Polish-Ukrainian border in *** In 2020 and 2022, we conducted two online questionnaires with human milk bank personnel to assess the impact of these emergencies on the human milk banking sector and its preparedness to face them. All 16 human milk bank entities operating in Poland were contacted and invited to participate in the study. For the first questionnaire, which was distributed in 2020, we obtained a 100% response rate. For the second questionnaire, the response rate was 88%, i.e., 14 out of 16 human milk banks completed the questionnaire. We compared these two emergencies in terms of the extent to which the potential of the Polish human milk bank network was exploited to support vulnerable infants who were not *** and discussion Our findings indicate that recommendations to provide donor human milk to infants separated from their mothers during the COVID-19 pandemic were never fully implemented. Meanwhile, during the refugee crisis, national legislation allowing equal access to public healthcare for Ukrainian citizens were rapidly implemented, enabling a more effective response by human milk banks to support vulnerable infants. However, no specific measures were introduced to support refugees outside the standard criteria for donor human milk provision. Our results highlight the limited response from the sector during emergencies and the underutilization of the potential of a nationwide network of professional human milk banks. Drawing on Polish experiences, we emphasize the importance of having procedures and legal regulations regarding human milk banking in place even in non-crisis settings, which would facilitate a rapid emergency response. We

关键词： COVID-19   PUBLIC HEALTH   Health Services   PAEDIATRICS   Health Services Accessibility   EMERGENCY-DEPARTMENT VISITS   QUALITATIVE EVIDENCE   PERCEPTIONS   SERVICES   CHILDREN   REASONS   IMPACT   SARS  

摘要： Objective Reductions in paediatric unscheduled healthcare utilisation were seen during the COVID-19 pandemic, with concerns around their impact on children's health. The reasons for these changes are not well described. This review aims to explore the factors reported by parents that influenced their decision-making around accessing paediatric unscheduled healthcare during the COVID-19 *** Mixed methods rapid review and thematic synthesis based on the Enhancing Transparency of Reporting the Synthesis of Qualitative research *** sources MEDLINE, Embase, Web of Science, PsycEXTRA, PsycINFO, Global Health, Global Index Medicus, Dissertations and Theses Global, Google Scholar and OAISter. Studies published from January 2020 to July 2023 were *** criteria for selecting studies Qualitative, quantitative and mixed methods studies that assessed the perspectives of parents on decisions to access or delay or avoid accessing paediatric unscheduled healthcare during the COVID-19 *** extraction and synthesis Nvivo 14.23.0 was used to code results the of the primary studies and develop themes, following a thematic synthesis *** Twelve studies were included, all from high-income settings, mainly in Europe. The studies were conducted across varying times and levels of COVID-19-related restrictions. The principal descriptive themes identified were (i) concerns about COVID-19 infection, (ii) balancing and navigating risks, (iii) perception of healthcare service status and conditions and (iv) perception of information and advice. These were developed into analytic themes to further describe the decision-making *** Parents balanced a range of risks, concerns, advice and responsibilities when considering accessing paediatric unscheduled healthcare during the COVID-19 pandemic. External sources of advice and information were important; misconceptions around public health advice may reflect the multitude of inf

关键词： CRITICAL-CARE PHYSICIANS   PSYCHOMETRIC PROPERTIES   RESIDENT PHYSICIANS   SURGICAL RESIDENTS   PTSD   SYMPTOMS   PREVALENCE   DISTRESS   TRAUMA   IMPACT  

摘要： Importance The COVID-19 pandemic placed many physicians in situations of increased stress and challenging resource allocation decisions. Insight into the prevalence of posttraumatic stress disorder in physicians and its risk factors during the COVID-19 pandemic will guide interventions to prevent its development. Objective To determine the prevalence of posttraumatic stress disorder (PTSD) among physicians during the COVID-19 pandemic and examine variations based on factors, such as sex, age, medical specialty, and career stage. Data Sources A Preferred Reporting Items for Systematic Reviews and Meta-analyses-compliant systematic review was conducted, searching MEDLINE, Embase, and PsychInfo, from December 2019 to November 2022. Search terms included MeSH (medical subject heading) terms and keywords associated with physicians as the population and PTSD. Study Selection Peer-reviewed published studies reporting on PTSD as a probable diagnosis via validated questionnaires or clinician diagnosis were included. The studies were reviewed by 6 reviewers. Data Extraction and Synthesis A random-effects meta-analysis was used to pool estimates of PTSD prevalence and calculate odds ratios (ORs) for relevant physician characteristics. Main Outcomes and Measures The primary outcome of interest was the prevalence of PTSD in physicians, identified by standardized questionnaires. Results Fifty-seven studies with a total of 28 965 participants and 25 countries were included (of those that reported sex: 5917 of 11 239 [52.6%] were male and 5322 of 11 239 [47.4%] were female; of those that reported career stage: 4148 of 11 186 [37.1%] were medical trainees and 7038 of 11 186 [62.9%] were attending physicians). The estimated pooled prevalence of PTSD was 18.3% (95% CI, 15.2%-22.8%; I-2 = 97%). Fourteen studies (22.8%) reported sex, and it was found that female physicians were more likely to develop PTSD (OR, 1.93; 95% CI, 1.56-2.39). Of the 10 studies (17.5%) reporting age, younger ph

关键词： Viral infection   Epidemiology  

摘要： The COVID-19 pandemic has flooded open databases with population-level data. However, individual-level structured data, such as the course of disease and contact tracing information, is almost non-existent in open databases. Publish a structured and cleaned COVID-19 dataset with the course of disease and contact tracing information for easy benchmarking of COVID-19 models. We gathered data from Taiwanese open databases and daily news reports. The outcome is a structured quantitative dataset encompassing the course of the disease of Taiwanese individuals, alongside their contact tracing information. Our dataset comprises 579 confirmed cases covering the period from January 21, to November 9, 2020, when the original SARS-CoV-2 virus was most prevalent in Taiwan. The data include features such as travel history, age, gender, symptoms, contact types between cases, date of symptoms onset, confirmed, critically ill, recovered, and dead. We also include the daily summary data at population-level from January 21, 2020, to May 23, 2022. Our data can help enhance epidemiological modelling.

关键词： RESISTANCE   EMOTIONS   POLITICS  

摘要： The article examines the affective dynamics of collective survival and resistance under Israeli settler colonialism in the Gaza Strip. Focusing on Gaza as an under-researched enclave of Israeli settler colonialism, it analyzes how young Palestinians renegotiated their affective bonds in response to two coinciding deadly events: the COVID-19 pandemic and the 2021 Israeli bombings. Theoretically, we extend the politics of emotions and affect to encompass experiences of settler-colonial violence. Drawing on original interviews with Palestinians in Gaza, we trace how affective bonds were impacted among families, friends, and neighbors and, from a transpersonal perspective, across the political community. We show how settler colonialism shaped responses to the pandemic, deepening existing inequalities and causing social frictions. The bombings, by contrast, triggered a unified response of pure terror and universal concern for collective survival. The military targeting of homes was countered by practices of physical and emotional togetherness in the face of death. Overall, our study shows how (i) different kinds of mortal dangers are experienced politically by colonized people, (ii) these experiences are conditioned by collective histories of colonial violence, and that (iii) they constitute expressions of collective affective life, necessary for the preservation of peoplehood amidst colonial oppression. L'article examine la dynamique affective de la survie collective et de la r & eacute;sistance sous le colonialisme isra & eacute;lien dans la bande de Gaza. En se concentrant sur Gaza en tant qu'enclave peu & eacute;tudi & eacute;e du colonialisme isra & eacute;lien, il analyse comment les jeunes Palestiniens ont ren & eacute;goci & eacute; leurs liens affectifs en r & eacute;ponse & agrave; deux & eacute;v & eacute;nements mortels co & iuml;ncidant, la pand & eacute;mie de Covid-19 et les bombardements isra & eacute;liens de 2021. D'un point de vue th & eacute;orique, n

关键词： COVID-19   primary prevention   infection control  

摘要： Objective To assess the level of compliance with COVID-19 preventive measures and compliance-associated factors in the Rwanda community. Design Cross-sectional study. Settings Country-wide community survey in Rwanda. Participants 4763 participants were randomly sampled following the sampling frame used for the recent Rwanda Demographic Health Survey. Participants were aged between 22 years and 94 years. Outcomes The participants' compliance with three preventive measures (wearing a face mask, washing hands and social distancing) was the main outcome. Methods From 14 February 2022 to 27 February 2022, a cross-sectional survey using telephone calls was conducted. Study questionnaires included different questions such as participants' demographics and compliance with COVID-19 preventives measures. Verbal consent was obtained from each participant. The compliance on three main preventive measures (wearing a mask, washing hands and social distancing) were the main outcomes. Univariate and multivariable logistic regression analyses were performed to evaluate factors associated with compliance (age, gender, level of education, socioeconomic status). Results Compliance with the three primary preventive measures (washing hands 98%, wearing a mask 97% and observing social distance 98%) was at a rate of 95%. The respondents' mean age was 46 +/- 11 SD (range 22-98) years. In addition, 69% were female and 86% had attended primary education. Bivariate and regression analyses indicated a significant association among the three primary preventive measures (p<0.05). The results showed factors associated significantly between the different models (p<0.05): proper mask use and social distancing in the hand washing model; hand washing, social distancing, avoiding handshakes and not attending gatherings in the proper mask use model; hand washing and avoiding handshakes in the social distancing model. Conclusion Compliance with the three key preventive measures against COVID-19 was high

关键词： HIV, Harm reduction   COVID-19   Mixed method   Drop in center   High risk women   OUTBREAK   HEALTH   PEOPLE   IMPACT   DRUGS  

摘要： BackgroundThe COVID-19 pandemic has posed significant challenges to nations worldwide, affecting various sectors of society. Women's HIV harm reduction centers, which provide critical services, have also been affected by these difficulties. This study aimed to examine the challenges of the COVID-19 pandemic on the services offered by women's HIV harm reduction centers from the perspective of *** convergent mixed-method design was utilized to gain in-depth insights into the challenges of COVID-19 on the services provided by women's HIV harm reduction centers, counseling centers, and night shelters that cater to women at risk, such as drug users, sex workers, and the homeless population, in three provinces (Tehran, Khuzestan, and Kermanshah) in Iran. The study was conducted from January to May 2023. The quantitative aspect of the study employed a cross-sectional method with a sample size of 430 individuals. A researcher-developed questionnaire was used to assess a range of services. The qualitative part of the study involved traditional content analysis and included 32 individual interviews. The integration of qualitative and quantitative results was performed during the interpretation phase to provide a comprehensive understanding of the challenges of COVID-19 on women's HIV harm reduction *** the quantitative phase, the mean age of women was 39.0 +/- 10.2 years. 165 women reported a history of COVID-19, which accounts for 38.4% of the total. More than half of them (n = 102, 61.8%) recovering at home. The majority of women (n = 365, 84.9%) mentioned receiving the COVID-19 vaccine. COVID-19 diagnostic tests were conducted for 74.2% (n = 319) of women. Women expressed higher satisfaction with the services (HIV prevention services, and accommodation services) before the COVID-19 pandemic compared to the satisfaction during the pandemic. The qualitative analysis identified emerging challenges related to the COVID-19 pandemic in two categories: