关键词： cancer   covid-19  

摘要： This cross-sectional study assesses changes in levels of public trust in US government health agencies providing cancer information.

摘要： Healthcare workers experienced significant disruptions to both their personal and professional lives throughout the COVID-19 pandemic. How healthcare workers were impacted varied, depending on area of specialization, work setting, and factors such as gender. Dietetics is a female-dominated profession and the differential impact on women of the COVID-19 pandemic has been widely reported. While researchers have explored Registered Dietitians’ (RDs) experiences during the pandemic, none have looked explicitly at their experiences of redeployment. The objectives of this study were to better understand: (i) the impact of COVID-19 (and related redeployments) on the work-lives of RDs, (ii) what types of COVID-19 related supports and training were made available to these RDs, and (iii) the impact of RD redeployment on access to RD services. An online survey was administered in June 2022. Any RD that that was publicly-employed in Canada during the pandemic was eligible to participate. The survey included questions related to respondent demographics, professional details, redeployment and training. We conducted descriptive analyses on the quantitative data. The survey was completed by 205 eligible RDs. There were notable differences between public health and clinical RDs’ redeployment experiences. Only 17% of clinical RDs had been redeployed, compared to 88% of public health RDs. Public health RDs were redeployed for longer and were more likely to be redeployed to roles that did not required RD-specific knowledge or skills. The most commonly reported mandatory training was for proper use of personal protective equipment. The most commonly reported reasons for a lengthy absence from work were anxiety about contracting COVID-19, school closures and limited child care availability. Public health RDs are at the forefront of campaigns to reduce the burden of chronic disease, improve health equity and enhance the sustainability of food systems. Close to 90% of these RDs were redepl

关键词： Corneal nerves   COVID-19   Dendritic cell   Neuroprotection   Vaccination   DIABETIC PERIPHERAL NEUROPATHY   CONFOCAL MICROSCOPY  

摘要： To examine corneal subbasal nerve changes in patients who received vaccination against SARS-CoV-2 virus and underwent COVID-19 infection compared to infected non-vaccinated patients and healthy controls. Twenty-nine eyes of 29 vaccinated patients (mean age: 36.66 +/- 12.25 years) within six months after PCR or Ag test proven COVID-19 infection and twenty-eight eyes of 28 age-matched infected, non-vaccinated patients (mean age: 42.14 +/- 14.17 years) were enrolled. Twenty-five age-matched healthy individuals (mean age: 47.52 +/- 18.45 years) served as controls. In vivo confocal microscopy (Heidelberg Retina Tomograph II Rostock Cornea Module, Germany) was performed in each group. Corneal subbasal nerve plexus morphology and corneal dendritic cells (DC) were evaluated. Significantly higher corneal nerve fiber density (P < 0.001), nerve branch density (P < 0.001), nerve fiber length (P < 0.001), total branch density (P = 0.007), nerve fiber area (P = 0.001) and fractal dimension (P < 0.001) values were observed in vaccinated patients after COVID-19 infection compared to the non-vaccinated group. Significantly higher DC density was observed in the non-vaccinated group compared to the control group (P = 0.05). There was a statistically significant difference in the size of mature DCs (P < 0.0001) but the size of immature DCs did not differ significantly among the 3 groups (P = 0.132). Our results suggest that SARS-CoV-2 vaccination may have a protective effect against the complications of COVID-19 disease on the corneal subbasal nerve fibers.

关键词： COVID-19  

摘要： The COVID-19 pandemic has significantly impacted food security in Indonesia, underscoring the urgent need for strategic agricultural budget allocation to address vulnerabilities in the food system. This study aims to evaluate budget allocation strategies to enhance food security resilience during COVID-19. The research problem focuses on the inadequacies in current budget techniques to effectively support food production and distribution amidst disruptions like the pandemic. The primary objective is to develop tailored frameworks that optimise budget allocations for sustainable food security in Indonesia's socio-economic and geographical context. Employing a multi-dimensional research methodology, this study engages key stakeholders from the Ministry of Agriculture, the Ministry of Finance, and the Ministry of National Development Planning to gather comprehensive insights. The research methodology involves in-depth interviews, focus group discussions, and data collection from both primary and secondary sources. The systematic analysis for decision-making employs the Analytical Hierarchy Process (AHP), supported by the Expert Choice 2000 programme. The results highlight the critical importance of a resilient framework that integrates short-term emergency responses with long-term sustainable strategies to enhance food production, distribution, and access. Policy implications highlight the proactive implementation of advanced agricultural technologies and the use of sensitivity analysis to inform strategic budget allocations. The study's findings provide actionable guidance for policymakers to strengthen food security measures, mitigate socio-economic disruptions during crises, and enhance Indonesia's disaster preparedness efforts, thereby contributing to Indonesia's resilient and sustainable food security framework. © 2024, The Authors. All rights reserved.

关键词： COVID-19   B-cell lymphoma   Persistent infection   Anti-CD20   Bendamustine  

摘要： BackgroundThe global impact of the coronavirus disease 2019 (COVID-19) pandemic has resulted in significant morbidity and mortality. Immunocompromised patients, particularly those treated for B-cell lymphoma, have shown an increased risk of persistent infection with SARS-CoV-2 and severe outcomes and mortality. Multi-mutational SARS-CoV-2 variants can arise during the course of such persistent cases of COVID-19. No optimal, decisive strategy is currently available for patients with persistent infection that allows clinicians to sustain viral clearance, determine optimal timing to stop treatment, and prevent virus reactivation. We introduced a novel treatment combining antivirals, neutralizing antibodies, and genomic analysis with frequent monitoring of spike-specific antibody and viral load for immunocompromised patients with persistent COVID-19 infection. The aim of this retrospective study was to report and evaluate the efficacy of our novel treatment for immunocompromised B-cell lymphoma patients with persistent COVID-19 *** retrospective descriptive analysis had no controls. Patients with B-cell lymphoma previously receiving immunotherapy including anti-CD20 antibodies, diagnosed as having COVID-19 infection, and treated in our hospital after January 2022 were included. We selected anti-SARS-CoV-2 monoclonal antibodies according to subvariants. Every 5 days, viral load was tested by RT-PCR, with antivirals continued until viral shedding was confirmed. Primary outcome was virus elimination. Independent predictors of prolonged viral shedding time were determined by multivariate Cox ***-four patients were included in this study. Thirty-five patients received rituximab, 19 obinutuzumab, and 26 bendamustine. Median treatment duration was 10 (IQR, 10-20) days; 22 patients received combination antiviral therapy. COVID-19 was severe in 16 patients, and critical in 2. All patients survived, with viral shedding confirmed at median 28

关键词： Ivermectin   Double-blind   Randomized placebo-controlled clinical trial   RT-PCR-confirmed Covid-19 infection   World Health Organization Clinical Progression Scale   Viral load   Serum ivermectin levels  

摘要： BackgroundEvidence on ivermectin as a treatment for Covid-19 is controversial. A Cochrane review concluded that the efficacy and safety of ivermectin is uncertain (evidence up to April 2022) and WHO recommended its use only in the setting of clinical trials. This study aimed to assess the efficacy and safety of oral ivermectin in hospitalized patients with mild to moderate *** design and methodsA double-blind, randomized placebo-controlled clinical trial was conducted among RT-PCR-confirmed, adults, hospitalised within the first four days of symptoms. Patients received oral ivermectin 24 mg or placebo daily for five days. RT-PCR was repeated on days five and ten. Clinical progression was monitored using the World Health Organization Clinical Progression Scale. Serum ivermectin levels were measured on days three, five, and seven. The primary outcome was the difference in the viral load between day zero and ten in the two *** of 1699 patients screened, 249 underwent randomization and 127 received ivermectin, and 122 placebo. D10 median viral load for E gene (IQR) was 2,000 copies/mL (100 - 20,500) with ivermectin (n = 80) and 4,100 copies/mL (1,000-65,600) with placebo (n = 81, p = 0.028), per protocol analysis. The difference in Log viral load between day zero and ten between ivermectin and placebo was 3.72 and 2.97 respectively (p = 0.022). There was no significant difference in the WHO clinical progression scale or the adverse effects. Ivermectin blood levels taken before or with meals were not significantly different. Only 7 and 17 patients achieved blood levels above 160ng/ML and 100ng/ML respectively and they did not achieve a significantly lower viral *** ivermectin resulted in statistically significant lower viral load in patients with mild to moderate Covid-19, it had no significant effect on clinical *** registration numberSLCTR/2021/020, Sri Lanka Clinical Trials Registry. 19/07/2021.

关键词： candidemia   COVID-19   incidence   mortality   CRITICALLY-ILL PATIENTS   PROGNOSTIC-FACTORS   CANDIDIASIS   IMPACT  

摘要： During the COVID-19 pandemic, an increase in the incidence of bloodstream infections caused by fungi of the Candida genus, also known as candidemia, was observed in patients with SARS-CoV-2 infection. This study aimed to assess the incidence of candidemia, the factors related to COVID-19-associated candidemia (CAC), and prognostic factors. A non-concurrent cohort of 87 cases of patients aged over 18 years with candidemia between March 2020 and February 2022 was evaluated. Incidence density (ID) was calculated by the number of patient-days during the period. All causes of mortality within 30 days of observation were considered. Logistic regression and Cox proportional hazards regression were used, respectively, to determine factors associated with CAC and prognostic factors. Values <0.05 were considered significant. The ID of CAC was eight times higher than candidemia in patients without COVID-19 [2.40 per 1000 person-days vs. 0.27 per 1000 person-days; P < .01]. The corticosteroid therapy was as an independent factor associated with CAC [OR = 15.98 (3.64-70.03), P < .01], while abdominal surgery was associated with candidemia in patients without COVID-19 [OR = 0.09 (0.01-0.88), P = .04]. Both patients with and without COVID-19 had a high 30 days-mortality rate (80.8% vs. 73.8%, respectively; P = .59). Liver disease [HR = 3.36 (1.22-9.27); P = .02] and the Charlson score [HR = 1.17 (1.01-1.34); P = .03] were independent factors of death, while the use of antifungals [HR = 0.15 (0.07-0.33); P < .01] and removal of the central venous catheter [HR = 0.26 (0.12-0.56); P < .01] independently reduced the risk of death. These findings highlight the high incidence of candidemia in COVID-19 patients and its elevated mortality.

关键词： EXPLANATIONS   CHILDHOOD   CURIOSITY  

摘要： Question-asking is a crucial tool for acquiring information about unseen entities, such as viruses; thus, examining children's questions within the context of COVID-19 is particularly important for understanding children's learning about the coronavirus. The study examined 3-12-year-old children's questions and teachers' responses about the COVID-19 pandemic in T & uuml;rkiye, a non-Western developing context, and the United States, a Western cultural context. A total of 119 teachers from T & uuml;rkiye and 95 teachers from the US participated in the study. Teachers completed an online survey consisting of a demographic form and a questionnaire asking them to report three questions about COVID-19 asked by children in their classrooms and their responses to these questions. We analyzed children's questions and teachers' responses for their type and content and examined demographic factors associated with children's questions and teachers' responses. Consistent with the literature, children from T & uuml;rkiye asked fewer explanation-seeking (i.e., why/how) questions than children from the United States. Children asked questions about viruses and precautions. Teachers responded to children's questions realistically in both countries. The findings have important implications for how children gain knowledge from teachers when discussing health, disease, and virus topics in two countries.

关键词： Environmental Sensitivity   adolescence   COVID-19 pandemic   emotions   longitudinal study   SENSORY-PROCESSING SENSITIVITY   DIFFERENTIAL SUSCEPTIBILITY   MENTAL-HEALTH   CHILDREN   STRESS   SCHOOL   ACT  

摘要： Introduction The COVID-19 pandemic significantly impacted the emotional well-being of adolescents worldwide. Some studies suggested that individuals with high Environmental Sensitivity may have been more likely to experience poor psychological adjustment during the pandemic than those with lower sensitivity. However, there is still limited research on how emotional responses varied across different stages of the pandemic and whether Environmental Sensitivity increased adolescents' vulnerability to the psychological impact of prolonged pandemic *** To address this gap, this study used a three-year longitudinal design (2020-2022) with a sample of 453 adolescents. They completed an online survey measuring their positive and negative emotions throughout the pandemic period, with Environmental Sensitivity considered a time-invariant *** The results revealed that all participants, regardless of their level of Environmental Sensitivity, experienced a decrease in positive emotionality between the first and second years. However, this trend reversed, showing an increase between the second and third years. Regarding negative emotions, highly sensitive adolescents experienced a significant linear increase over time. In contrast, low-and medium-sensitive adolescents exhibited a quadratic trend, with a notable increase in negative emotions between the first and second years, followed by a slight decrease between the second and third *** These findings provide further evidence of the negative impact of the pandemic on adolescents' emotional well-being. They also support the notion that Environmental Sensitivity is associated with individuals' ability to respond and adjust to adverse life events, with significant implications for future research and practice.