关键词： COVID-19   Pulmonary fibrosis   Anti-fibrotic medications   Meta-analysis   COVID-19   PIRFENIDONE   NINTEDANIB   SAFETY  

摘要： Objectives: The impact of anti-fibrotic medications on pulmonary fibrosis caused by COVID-19 remains inconclusive and lacks systematic investigation. This study assessed the efficacy of anti-fibrotic drugs in addressing post-COVID-19 lung fibrosis. Methods: We searched PubMed, Web of Science, Embase, and the Cochrane Library until June 15, 2024. The meta-analysis was performed using Review Manager. Heterogeneity was evaluated utilizing I2 statistic, and publication bias was assessed via funnel plots. Results: The study (CRD42024552847) included 7 trials with 496 participants. No significant differences were observed in chest CT score (SMD =-0.60, 95% CI:-1.33 to 0.12, P = 0.10), length of hospital stay (MD =-1.34, 95% CI:-4.39 to 1.70, P = 0.39), and mortality (OR = 0.91, 95% CI: 0.50 to 1.64, P = 0.75) between anti-fibrosis and standard treatment groups. Notable improvements in pulmonary function were observed with anti-fibrotic drugs, as indicated by FEV1%pred (MD = 23.95, 95% CI: 12.24 to 35.67, P < 0.0 0 01) and FEV1/FVC (MD = 18.17, 95% CI: 11.96 to 24.38, P < 0.0 0 0 01). Conclusions: Anti-fibrotic medications may help reduce fibrotic lesions and improve pulmonary function in post-COVID-19 pulmonary fibrosis, but their practical use is currently based more on theory than on solid medical evidence. Currently, in clinical practice, the use of anti-fibrotic drugs in these patients primarily relies on empirical treatment. Further clinical studies are imperative to bolster its credibility for future applications. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Japanese spotted fever   Poisson regression   Incidence rate   COVID-19 pandemic   SCRUB TYPHUS   PREFECTURE   DISEASE  

摘要： Introduction: The objective of this study is to evaluate the epidemiological characteristics of Japanese Spotted Fever (JSF) cases reported through the National Epidemiological Surveillance of Infectious Disease (NESID) system in Shimane Prefecture, Japan, from 2000 to 2022, encompassing the periods before and during the COVID-19 pandemic period. Methods: A retrospective analysis was conducted on JSF cases reported to the NESID system in Shimane Prefecture between 2000 and 2022. Population data were obtained from the Statistical Information of Shimane. Poisson regression analysis was employed to examine the relationship between the annual prevalence rate of JSF and the COVID-19 pandemic. Results: A total of 301 JSF cases were analyzed during the study period. Even the pre-COVID-19 pandemic period, a gradual and significant increase in the prevalence rate was observed (prevalence rate = 1.03, 95% CI: 1.01-1.05; p = 0.01), and a rapid increase was noted since 2020 (prevalence rate = 1.57, 95% CI: 1.39-1.78; p < 0.01). The slope during the pre-COVID-19 pandemic period was estimated to have significantly increased (p < 0.01). Conclusions: Our findings suggest that while the prevalence rate of JSF had exhibited a slight increase in the years preceding the COVID-19 pandemic, it demonstrated a more significant increase following the pandemic in Shimane Prefecture. JSF has increased since 2020 and may be linked to COVID-19 pandemic. The COVID-19 pandemic has had a substantial impact on global health, underscoring the importance of investigating the prevalence of specific infectious diseases and other health-related indicators to accurately assess the pandemic's impact.

关键词： COVID   depression   older adults   cognition   dementia   OLDER AFRICAN-AMERICANS   NATIONAL-SURVEY   UNITED-STATES   PREVALENCE   HEALTH   RETIREMENT   DISORDERS   ADULTS  

摘要： Objective: To explore differences in depressive symptoms for older adults (Black, Latinx, and White) by cognitive status during the 2020 COVID-19 pandemic. Methods: Data from the Health and Retirement Study identified older adults as cognitively normal, cognitively impaired without dementia (CIND), and persons living with dementia (PLWD). Multiple linear regression analyses examined associations between cognitive status and depressive symptoms among these racialized groups. Results: Compared to the cognitively normal older adults racialized as Black, those with CIND reported higher depressive symptoms during the pandemic (overall and somatic) and PLWD had higher somatic symptoms (p < .01). Older adults racialized as White with CIND reported higher somatic (p < .01) symptoms compared to cognitively normal older adults racialized as White. Discussion: The COVID-19 pandemic was a challenging event among older adults racialized as Black with CIND and PLWD. Future studies should examine if these depressive symptoms persist over time.

关键词： Trauma   COVID-19   Mental health   Ethiopia   Physical health   Stress   Psychosis   LIFE EVENTS CHECKLIST   PSYCHOMETRIC PROPERTIES   PSYCHOLOGICAL TRAUMA   CHRONIC DISEASE   PREVALENCE   ASSOCIATION   SYMPTOMS   CRITERIA   OUTCOMES  

摘要： Background: The COVID-19 pandemic has profoundly impacted the economic, psychological, and social wellbeing of people in Ethiopia. Pandemic-related fears can exacerbate anxiety and depression symptoms among those with pre-existing physical and mental health conditions as well as those with prior exposure to traumatic events. Methods: We used data from the Ethiopia NeuroGAP-Psychosis study (898 cases and 941 controls with and without a diagnosis of psychosis respectively, 66% male, mean age = 37 years). Data was collected between November 2021 and June 2022 during the COVID-19 pandemic from four hospitals in Ethiopia (three in Addis Ababa and one in Jimma city). Structural equation modeling analysis was conducted to examine the associations between trauma exposure, physical health conditions (like arthristis, neurological disorders, diabetes), COVID-19 stress, and psychological distress (depression and anxiety symptoms). We assessed direct and indirect effects for mediation, and conducted multigroup analysis to examine moderation by case control status. Results: We found evidence that the impact of greater trauma exposure and physical health conditions on higher psychological distress was mediated through higher COVID-19 stress. Sociodemographic characteristics (older age and being maried) were associated with higher psychological distress, with these associations mediated through greater trauma, physical health conditions, and COVID-19 stress. Case-control status also moderated the associations between these variables, with the mediation effects being stronger in cases and weaker in controls. Further, cases reported greater trauma and psychological distress, while controls reported more physical health conditions and COVID-19 stress. Implications: Our findings uniquely assess the interaction of health and emergency related factors in understudied settings like Ethiopia. They underscore the importance of including daily hardships and environmental stressors, along wi

关键词： Long COVID   Post SARS-CoV-2   Symptoms   Prevalence   Risk factor   CARE  

摘要： Objectives: This study examines clinically confirmed long-COVID symptoms and diagnosis among individuals with COVID in England, aiming to understand prevalence and associated risk factors using electronic health records. To further understand long COVID, the study also explored differences in risks and symptom profiles in three subgroups: hospitalised, non-hospitalised, and untreated COVID cases. Methods: A population-based longitudinal cohort study was conducted using data from 1,554,040 individuals with confirmed SARS-CoV-2 infection via Clinical Practice Research Datalink. Descriptive statistics explored the prevalence of long COVID symptoms 12 weeks post-infection, and Cox regression models analysed the associated risk factors. Sensitivity analysis was conducted to test the impact of right-censoring data. Results: During an average 400-day follow-up, 7.4% of individuals with COVID had at least one long-COVID symptom after acute phase, yet only 0.5% had long-COVID diagnostic codes. The most common long-COVID symptoms included cough (17.7%), back pain (15.2%), stomach-ache (11.2%), headache (11.1%), and sore throat (10.0%). The same trend was observed in all three subgroups. Risk factors associated with long-COVID symptoms were female sex, non-white ethnicity, obesity, and pre-existing medical conditions like anxiety, depression, type II diabetes, and somatic symptom disorders. Conclusions: This study is the first to investigate the prevalence and risk factors of clinically confirmed longCOVID in the general population. The findings could help clinicians identify higher risk individuals for timely intervention and allow decision-makers to more efficiently allocate resources for managing long-COVID. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： COVID-19   Zinc   Severity   Nutritional risk factor  

摘要： Introduction: Various risk factors for developing severe coronavirus disease 2019 (COVID-19) have been reported. However, studies on the nutritional-related risk factors are limited. In this study, we investigated the effects of serum zinc deficiency on the severity of COVID-19. Methods: The study included a total of 60 COVID-19 patients who were admitted to Tsuyama Chuo Hospital between March 2020 and April 2021. We divided the patients into two categories based on serum levels of zinc (normal and latent zinc deficiency vs. zinc deficiency [<60 mu g/dL]) at the time of diagnosis. Severity of COVID19 was defined as the most exaggerated disease status during admission. The associations between serum zinc deficiency and the severity of COVID-19 were examined using a logistic regression model adjusted for potential confounders. Results: Patients who required oxygen therapy had a higher prevalence of comorbidities and poorer nutritional status, including zinc deficiency, than those who did not require oxygen therapy. Zinc deficiency was associated with an increased risk of COVID-19 severity, with an adjusted odds ratio of 7.29 (95% confidence interval: 1.70-31.18). . This result remained significant in the sensitivity analyses conducted after adjusting for patient background factors. Conclusions: Zinc deficiency at the time of COVID-19 diagnosis is an independent risk factor for severe disease. Our findings need to be validated in external studies.

关键词： COVID-19   Semi-structural models   Unobserved components   Potential output   Output gap   Bayesian estimation  

摘要： We perform several trend-cycle decompositions through the lens of two unobserved components models, herein estimated for Portugal and the euro area. Our procedure copes with the COVID-19's consequences by explicitly considering potentially larger second moments during that period. This is achieved through a set of pandemic- specific shocks affecting only the 2020-21 period and embedded into estimation through a piecewise linear Kalman filter. Our methodology generates negligible historical revisions in key smoothed variables when the sample period is expanded until 2021:4, since pandemic shocks absorb a great deal of data volatility with minimal impacts on filtered data revisions or estimated parameters. Furthermore, non-pandemic shock volatility remains largely unaffected by the pandemic period. Innovations affecting the cycle in our preferred model are the key propellers of GDP developments during the COVID-19 pandemic period.

关键词： Intensive care   Respiration   Artificial   Respiratory distress syndrome   Respiratory insufficiency   Pneumonia   Viral   RESPIRATORY-DISTRESS-SYNDROME   END-EXPIRATORY PRESSURE   ACUTE LUNG INJURY   CORONAVIRUS DISEASE 2019   RECRUITMENT   ADULTS  

摘要： Rationale: The positive end-expiratory pressure (PEEP) strategy in patients with coronavirus 2019 (COVID-19) acute respiratory distress syndrome (ARDS) remains debated. Most studies originate from the initial waves of the pandemic. Here we aimed to assess the impact of high PEEP/low FiO2 ventilation on outcomes during the second wave in the Netherlands. Methods: Retrospective observational study of invasively ventilated COVID-19 patients during the second wave. Patients were categorized based on whether they received high PEEP or low PEEP ventilation according to the ARDS Network tables. The primary outcome was ICU mortality, and secondary outcomes included hospital and 90-day mortality, duration of ventilation and length of stay, and the occurrence of kidney injury. Propensity matching was performed to correct for factors with a known relationship to ICU mortality. Results: This analysis included 790 COVID-ARDS patients. At ICU discharge, 32 (22.5%) out of 142 high PEEP patients and 254 (39.2%) out of 848 low PEEP patients had died (HR 0.66 [0.46-0.96]; P = 0.03). High PEEP was linked to improved secondary outcomes. Matched analysis did not change findings. Conclusions: High PEEP ventilation was associated with improved ICU survival in patients with COVID-ARDS.

关键词： COVID-19   Vaccination   Vaccine   Optic neuritis   SPECTRUM  

摘要： Objective. - To review cases of optic neuritis after COVID-19 vaccination and add similar cases to the literature. Methods. - Thorough PubMed and Scopus searches were conducted, and data from studies describing optic neuritis after COVID-19 vaccination were extracted, tabulated, pooled, and reviewed. Results. - We present 6 cases of optic neuritis following COVID-19 vaccination. Our literature search yielded 48 similar cases. All 54 cases were divided into 3 groups with respect to their serostatus: (1) double-seronegative or unknown serostatus optic neuritis cases, (2) myelin oligodendrocyte glycoprotein (MOG)-associated optic neuritis cases, and (3) aquaporin-4-associated optic neuritis cases. Data from each group were separately pooled and reviewed. While the most frequent vaccine among the anti-AQP4+ subgroup was BNT162b2 (Pfizer-BioNTech) (2/3), recombinant vaccines, e.g., AZD122 and ***2.s were mostly injected in the other subgroups (23/51). No significant gender inclination was seen among different subgroups. The mean interval from vaccination to symptom onset was less than one month in all subgroups; symptom manifestations mainly occurred after the first dose (28/54). Almost all cases showed improvement after steroid therapy +/- plasma exchange (52/54). Conclusion. - Despite having rare side effects such as optic neuritis, vaccination remains our most helpful protection against SARS-CoV-2. Nevertheless, larger studies are needed to ascertain the pathophysiology of such adverse effects. Likewise, the association between COVID-19 vaccination and optic neuritis warrants further investigation. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： COVID-19   images   political communication   political elites   United States   social media  

摘要： During national crises, political elites often rally around the flag, promoting a central message to restore unity and calm the public. COVID-19 provided such a crisis. But did elites rally? The pandemic occurred at a point of extreme polarization in the United States, which threatens the potential for a rally. In this article, we argue that messaging about masking during COVID-19 offers an opportunity to test the comparative effects of a rally versus polarization. To do so, we use a unique measure: visual public communication by members of Congress (MOCs). We extract 340,000 images from congressional Twitter and Facebook accounts and employ supervised machine-learning methods to identify when MOCs posted images of people wearing masks. We find evidence of both rally effects and polarization. Trump's actions are especially important: while Trump-loyal Republicans are less likely to post masks, all Republicans increased posting masks after Trump first appeared wearing a face mask.